INT273110

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) extracellular region (Bdnf) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) cytoplasmic membrane-bounded vesicle (Bdnf) protein complex (Gria1)
Anatomy Link Frequency
hippocampus 2
Bdnf (Rattus norvegicus)
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 50 97.08 Very High Very High Very High
amygdala 2 93.08 High High
antagonist 2 82.16 Quite High
Glutamate receptor 2 60.80 Quite High
long-term potentiation 18 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amnesia 6 8.88 Low Low
Shock 8 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the BDNF/mTOR pathway regulates these increases in GluR1 protein in synaptic plasma membranes, we injected into CA1 region of the dorsal hippocampus function-blocking anti-BDNF antibodies or rapamycin 15 min before training and sacrificed the animals 15 min after training.
BDNF/mTOR Spec (whether) Regulation (regulates) of Spec (whether) Positive_regulation (increases) of GluR1 protein in hippocampus associated with hippocampus
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.25
These experiments indicate that the BDNF/mTOR signaling pathway controls the learning-induced increase in GluR1 15 min or 3 h after training.
BDNF/mTOR Regulation (controls) of Positive_regulation (increase) of GluR1
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.22

General Comments

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