INT273118

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtor) Golgi apparatus (Mtor) endoplasmic reticulum (Mtor)
cytoplasm (Mtor) cytosol (Mtor) extracellular region (Bdnf)
Bdnf (Rattus norvegicus)
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 75 95.40 Very High Very High Very High
long-term potentiation 27 93.40 High High
Glutamate receptor 3 16.08 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 12 5.00 Very Low Very Low Very Low
Amnesia 9 5.00 Very Low Very Low Very Low
Decapitation 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that endogenous BDNF activates the hippocampal mTOR signaling cascade immediately after training.
BDNF Positive_regulation (activates) of mTOR
1) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
Subsequently we wanted to elucidate whether BDNF was the upstream activator of mTOR during memory consolidation.
BDNF Spec (whether) Positive_regulation (activator) of mTOR
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.07
Given that BDNF induces rapamycin-sensitive synaptic potentiation [9] and regulates translation of 5?
BDNF Positive_regulation (induces) of rapamycin
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.20

General Comments

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