INT273123

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 3.56
Pain Relevance 10.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hp) extracellular region (Hp) Golgi apparatus (Hp)
endoplasmic reticulum (Hp)
Anatomy Link Frequency
tail 1
brain 1
Hp (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 104 100.00 Very High Very High Very High
antiallodynic 741 99.76 Very High Very High Very High
antagonist 286 98.88 Very High Very High Very High
painful pain 143 98.84 Very High Very High Very High
withdrawal 468 98.40 Very High Very High Very High
tail-flick 26 98.12 Very High Very High Very High
Neuropathic pain 13 98.08 Very High Very High Very High
Endogenous opioid 52 97.20 Very High Very High Very High
Pain 169 96.92 Very High Very High Very High
Clonidine 143 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 26 99.14 Very High Very High Very High
Nociception 208 98.84 Very High Very High Very High
Neuropathic Pain 182 98.08 Very High Very High Very High
Pain 169 96.92 Very High Very High Very High
Hyperalgesia 13 94.24 High High
Headache 13 90.16 High High
Hypersensitivity 312 86.00 High High
INFLAMMATION 26 86.00 High High
Urological Neuroanatomy 13 63.92 Quite High
Targeted Disruption 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies performed in rodent brain membranes and human neuroblastoma cells showed that metabolites I and II of HP bind to ?
HP Binding (bind) of in brain associated with neuroblastoma
1) Confidence 0.25 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.30 Pain Relevance 0.29
Haloperidol and reduced HP show affinity for NMDA receptors, but their affinity for NMDA receptors is very low (Ki in the micromolar range) (Whittemore et al. 1997; Coughenour and Cordon 1997) in comparison to their affinity for ?
HP Binding (affinity) of associated with nmda receptor
2) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.22 Pain Relevance 1.05
Therefore, HP and its metabolites might act at any of these sites to produce their antiallodynic effects.
HP Binding (metabolites) of associated with antiallodynic
3) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.36 Pain Relevance 0.81
Haloperidol, HP metabolites I, II, III, and (?)
HP Binding (metabolites) of
4) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.17 Pain Relevance 1.01
Haloperidol and HP-Met-II showed affinity for ?
HP-Met Binding (affinity) of
5) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.41 Pain Relevance 0.87
1 receptors with less affinity than HP, but show much lower (HP-Met-II) or no affinity (metabolite I) for D2 receptors, whereas metabolite III has no affinity for either ?
HP Binding (affinity) of
6) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.31 Pain Relevance 0.30
1 receptor antagonist BD-1063 (Matsumoto et al. 1995; Hayashi and Su 2004) produced a response pattern very similar to that of HP and its metabolites, i.e., an antiallodynic effect that was fully reversed by the ?
HP Binding (metabolites) of associated with antagonist and antiallodynic
7) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.14 Pain Relevance 1.02
Haloperidol and reduced HP show affinity for NMDA receptors, but their affinity for NMDA receptors is very low (Ki in the micromolar range) (Whittemore et al. 1997; Coughenour and Cordon 1997) in comparison to their affinity for ?
HP Binding (affinity) of associated with nmda receptor
8) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.22 Pain Relevance 1.08
Secondly, HP-Met-III and (?)
HP-Met Binding (Secondly) of
9) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.10 Pain Relevance 0.62
The affinity of HP for ?
HP Binding (affinity) of
10) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.52 Pain Relevance 0.88
Previous studies have reported that HP and its metabolites I and II, as well as other antagonists of ?
HP Binding (metabolites) of associated with antagonist
11) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.25 Pain Relevance 1.25
In contrast, there are several arguments indicating that the antiallodynic effects of HP and its metabolites are due to their activity on ?
HP Binding (metabolites) of associated with antiallodynic
12) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.08 Pain Relevance 0.58
Previous studies have also found that HP and its metabolites did not modify heat-induced nociceptive pain (tail flick test) (Chien and Pasternak 1994; Cendán et al. 2005b), but data on their effect on mechanical nociceptive pain have not been previously reported.
HP Binding (metabolites) of in tail associated with tail-flick and painful pain
13) Confidence 0.20 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.47 Pain Relevance 1.15

General Comments

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