INT273132

Context Info Confidence 0.31 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.28 Pain Relevance 0.33

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS) nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)

FDPS (Homo sapiens)

Pain Link Frequency Relevance Heat pregabalin 156 96.80 Central nervous system 8 5.00 Pain 8 5.00 gABA 8 5.00 Neurobehavioral 4 5.00 agonist 4 5.00 Calcium channel 4 5.00 antagonist 4 5.00

Disease Link Frequency Relevance Heat Shock 164 98.96 Anxiety Disorder 556 95.16 Sleep Disorders 60 94.68 Stress 12 5.00 Generalized Anxiety Disorder 4 5.00 Bradycardia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To test drug effects on FPS during the unpredictable shock context, a Context (Neutral context, Unpredictable context) × Drug (4) ANOVA was employed.

Regulation (effects) of FPS associated with shock

1) Confidence 0.31 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.26 Pain Relevance 0

In our previous work, even though the drug manipulations did not affect FPS significantly, variation in baseline startle between drug conditions correlated significantly with differences in state anxiety and sedation as a result of drug administration (Baas et al. 2002a).

Neg (not) Regulation (affect) of FPS associated with anxiety disorder and sleep disorders

2) Confidence 0.19 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.54 Pain Relevance 0

First, the lack of significant effects of alprazolam on context-specific FPS could be a false negative.

Regulation (effects) of FPS

3) Confidence 0.19 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.17 Pain Relevance 0.12

Analyses on T scores revealed highly significant effects of cued FPS (F(1,19;GG??

Regulation (effects) of FPS

4) Confidence 0.19 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.32 Pain Relevance 0.22

General Comments

This test has worked.