INT273145

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL8A2) proteinaceous extracellular matrix (COL8A2) protein binding, bridging (COL8A2)
extracellular matrix organization (COL8A2)
Anatomy Link Frequency
endothelial cells 1
posterior 1
COL8A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 60.20 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 86.04 High High
Congenital Anomalies 42 76.32 Quite High
Cataract 8 71.76 Quite High
Non-genital Cutaneous Warts 6 66.64 Quite High
Corneal Edema 12 63.12 Quite High
Pressure And Volume Under Development 22 62.36 Quite High
Corneal Disease 18 58.04 Quite High
Aging 8 54.08 Quite High
Wrinkles 2 50.44 Quite High
Blindness 6 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Na-K ATPase pump site density in endothelial cells is decreased in FECD.
Negative_regulation (decreased) of FECD in endothelial cells
1) Confidence 0.40 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.72 Pain Relevance 0.06
In FECD corneas, Descemet membrane and its adjacent posterior collagenous contain similar collagen types to age-matched controls and immunohistochemical studies have disclosed fibrinogen/fibrin in the posterior collagenous layer in FECD, but not in normal Descemet membrane.
Negative_regulation (disclosed) of FECD in posterior
2) Confidence 0.29 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.12 Pain Relevance 0

General Comments

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