INT27315

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 9.84
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TPO) oxidoreductase activity (TPO) plasma membrane (TPO)
cellular nitrogen compound metabolic process (TPO) cytoplasm (TPO)
Anatomy Link Frequency
thyroid 3
plasma 2
blood 2
neck 1
sympathetic 1
TPO (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 39 99.74 Very High Very High Very High
nerve block 2 99.36 Very High Very High Very High
Pain 11 98.40 Very High Very High Very High
Dopamine 4 97.84 Very High Very High Very High
agonist 1 97.48 Very High Very High Very High
Opioid 3 97.04 Very High Very High Very High
antagonist 2 96.76 Very High Very High Very High
Endogenous opioid 1 92.80 High High
Catecholamine 6 91.12 High High
narcan 6 89.52 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 88 100.00 Very High Very High Very High
Hypertension 2 98.96 Very High Very High Very High
Thyroiditis 6 98.60 Very High Very High Very High
Hypothyroidism 2 98.60 Very High Very High Very High
Hypotension 18 98.44 Very High Very High Very High
Heart Rate Under Development 2 98.28 Very High Very High Very High
Pressure And Volume Under Development 6 97.84 Very High Very High Very High
Thyroid Disease 2 97.32 Very High Very High Very High
Ataxia 2 94.40 High High
Muscular Spasm 2 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Positive anti-thyroglobulin antibodies and anti-thyroid peroxidase (TPO) antibodies and slight elevation of TSH levels are consistent with subclinical hypothyroidism due to Hashimoto's thyroiditis.
Positive_regulation (elevation) of TPO in thyroid associated with hypothyroidism and thyroiditis
1) Confidence 0.45 Published 2005 Journal Intern. Med. Section Abstract Doc Link 16357456 Disease Relevance 1.13 Pain Relevance 0.13
When this increase in arterial blood pressure is reversed, MSA during ketamine is not changed from preketamine baseline recordings.
Neg (not) Positive_regulation (changed) of MSA in blood
2) Confidence 0.41 Published 2000 Journal Anesthesiology Section Body Doc Link 10638904 Disease Relevance 0 Pain Relevance 0
The MSA increase in response to the hypotensive challenge was fully maintained during anesthesia with S(+)-ketamine.
Positive_regulation (increase) of MSA
3) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11176089 Disease Relevance 0 Pain Relevance 0
RESULTS: Anesthesia with S(+)-ketamine (ketamine plasma concentration 713 +/- 295 microg/l) significantly increased MSA burst frequency (mean +/- SD; 18 +/- 6 to 35 +/- 11 bursts/min) and burst incidence (32 +/- 10 to 48 +/- 15 bursts/100 heartbeats) and was associated with a doubling of norepinephrine plasma concentration (from 159 +/- 52 to 373 +/- 136 pg/ml) parallel to the increase in MSA.
Positive_regulation (increase) of MSA in plasma
4) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11176089 Disease Relevance 0.11 Pain Relevance 0
Despite increased MSA and arterial pressure during S(+)-ketamine anesthesia, the increase in MSA in response to arterial hypotension is maintained.


Positive_regulation (increased) of MSA
5) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11176089 Disease Relevance 0 Pain Relevance 0
Despite increased MSA and arterial pressure during S(+)-ketamine anesthesia, the increase in MSA in response to arterial hypotension is maintained.


Positive_regulation (increase) of MSA
6) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11176089 Disease Relevance 0 Pain Relevance 0
The authors tested the hypothesis that racemic ketamine increases efferent muscle sympathetic activity (MSA) and maintains the muscle sympathetic response to hypotensive challenges.
Positive_regulation (increases) of MSA in sympathetic associated with ketamine, hypotension and multiple system atrophy
7) Confidence 0.41 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10638904 Disease Relevance 0.27 Pain Relevance 0.31
Hypotensive challenges similarly increased MSA both in the awake state and during ketamine anesthesia.
Positive_regulation (increased) of MSA
8) Confidence 0.41 Published 2000 Journal Anesthesiology Section Body Doc Link 10638904 Disease Relevance 0 Pain Relevance 0
RESULTS: Anesthesia with S(+)-ketamine (ketamine plasma concentration 713 +/- 295 microg/l) significantly increased MSA burst frequency (mean +/- SD; 18 +/- 6 to 35 +/- 11 bursts/min) and burst incidence (32 +/- 10 to 48 +/- 15 bursts/100 heartbeats) and was associated with a doubling of norepinephrine plasma concentration (from 159 +/- 52 to 373 +/- 136 pg/ml) parallel to the increase in MSA.
Positive_regulation (increased) of MSA in plasma
9) Confidence 0.41 Published 2001 Journal Anesthesiology Section Body Doc Link 11176089 Disease Relevance 0.13 Pain Relevance 0
The increase in MSA was accompanied by and correlated quite well with an increase in blood pressure.
Positive_regulation (increase) of MSA in blood associated with pressure and volume under development and multiple system atrophy
10) Confidence 0.41 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2596327 Disease Relevance 1.10 Pain Relevance 0.09
The increase in MSA correlated with the degree of discomfort from the ice water.
Positive_regulation (increase) of MSA associated with multiple system atrophy
11) Confidence 0.41 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2596327 Disease Relevance 0.83 Pain Relevance 0.09
In nine subjects with a large increase in MSA on ice water immersion, intracutaneous painful electrical stimulation to a level equalling the discomfort from the ice water was added, but it was not accompanied by any change in MSA.
Positive_regulation (increase) of MSA associated with pain and multiple system atrophy
12) Confidence 0.41 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2596327 Disease Relevance 0.88 Pain Relevance 0.10
As a rule, immersion evoked an increase in MSA, with a gradual decrease on emersion.
Positive_regulation (increase) of MSA associated with multiple system atrophy
13) Confidence 0.41 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2596327 Disease Relevance 0.53 Pain Relevance 0.06
Following the nerve block in the neck there was a strong increase of MSA accompanied by temporary hypertension and tachycardia.
Positive_regulation (increase) of MSA in neck associated with nerve block, heart rate under development, hypertension and multiple system atrophy
14) Confidence 0.40 Published 1985 Journal Brain Section Abstract Doc Link 4005530 Disease Relevance 0.82 Pain Relevance 0.30
Positive anti-thyroglobulin antibodies and anti-thyroid peroxidase (TPO) antibodies and slight elevation of TSH levels are consistent with subclinical hypothyroidism due to Hashimoto's thyroiditis.
Positive_regulation (elevation) of anti-thyroid peroxidase in thyroid associated with hypothyroidism and thyroiditis
15) Confidence 0.17 Published 2005 Journal Intern. Med. Section Abstract Doc Link 16357456 Disease Relevance 1.13 Pain Relevance 0.13
In conclusion: (1) the postural stimulation of AVP release is blunted in MSA; (2) this postural rise in AVP is not inhibited by a dopamine agonist or opioid antagonist in MSA suggesting loss of dopaminergic and opioid pathways involved in AVP release; (3) endogenous opioids do not contribute to orthostatic hypotension in MSA; (4) patients with MSA are supersensitive to the hypotensive effects of an acute L-DOPA infusion.
Positive_regulation (blunted) of MSA associated with dopamine, multiple system atrophy, pressure volume 2 under development, antagonist, agonist, endogenous opioid, hypotension and opioid
16) Confidence 0.09 Published 1983 Journal Brain Section Abstract Doc Link 6850280 Disease Relevance 1.13 Pain Relevance 0.88
Antithyroper-oxidase antibodies (anti-TPO) were highly elevated and thyroid function tests had evidenced a clinically significant hypothyroidism.
Positive_regulation (elevated) of anti-TPO in thyroid associated with thyroid disease
17) Confidence 0.06 Published 2008 Journal Panminerva Med Section Abstract Doc Link 18927530 Disease Relevance 1.76 Pain Relevance 0.17

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