INT273159

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
testis 1
corneal endothelial cells 1
thyroid gland 1
trachea 1
salivary gland 1
CHED1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 40 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
fibrosis 16 5.00 Very Low Very Low Very Low
peripheral neuropathy 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Corneal Dystrophies 16 99.96 Very High Very High Very High
Disease 200 99.48 Very High Very High Very High
Penetrating Wounds 8 97.16 Very High Very High Very High
Syndrome 40 94.76 High High
Amyloidosis 24 87.76 High High
Keratitis 24 85.24 High High
Uveitis 8 84.68 Quite High
Corneal Opacity 120 73.44 Quite High
Corneal Edema 48 71.60 Quite High
Ocular Toxicity (including Many Sub-types) 24 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHED1 progresses slowly over 5–10 years, but CHED2 remains stationary throughout life.


Gene_expression (progresses) of CHED1
1) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
For example why is clinical disease restricted to the cornea CHED2, when it is known that the SLC4A11 gene is strongly expressed in the numerous parts of the body (including kidney, salivary gland, thyroid gland, testis and trachea)?
Gene_expression (known) of CHED2 in kidney associated with disease
2) Confidence 0.32 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
CHED can be confused with other congenital causes of corneal opacification, such as CSCD and Peters anomaly.
Gene_expression (confused) of CHED
3) Confidence 0.32 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.72 Pain Relevance 0
As with PPCD, the corneal endothelial cells in CHED express cytokeratin in contrast to normal corneal endothelium [143], but unlike PPCD the endothelial layer less often becomes multilayered [144].
Gene_expression (express) of CHED in corneal endothelial cells
4) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.09 Pain Relevance 0
For example why is clinical disease restricted to the cornea CHED2, when it is known that the SLC4A11 gene is strongly expressed in the numerous parts of the body (including kidney, salivary gland, thyroid gland, testis and trachea)?
Gene_expression (known) of CHED2 in trachea associated with disease
5) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
For example why is clinical disease restricted to the cornea CHED2, when it is known that the SLC4A11 gene is strongly expressed in the numerous parts of the body (including kidney, salivary gland, thyroid gland, testis and trachea)?
Gene_expression (known) of CHED2 in testis associated with disease
6) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
For example why is clinical disease restricted to the cornea CHED2, when it is known that the SLC4A11 gene is strongly expressed in the numerous parts of the body (including kidney, salivary gland, thyroid gland, testis and trachea)?
Gene_expression (known) of CHED2 in salivary gland associated with disease
7) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
For example why is clinical disease restricted to the cornea CHED2, when it is known that the SLC4A11 gene is strongly expressed in the numerous parts of the body (including kidney, salivary gland, thyroid gland, testis and trachea)?
Gene_expression (known) of CHED2 in thyroid gland associated with disease
8) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0

General Comments

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