INT27316

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 7.26
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TPO) oxidoreductase activity (TPO) plasma membrane (TPO)
cellular nitrogen compound metabolic process (TPO) cytoplasm (TPO)
Anatomy Link Frequency
blood 1
sympathetic 1
TPO (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 2 100.00 Very High Very High Very High
methadone 2 99.98 Very High Very High Very High
Clonidine 34 99.80 Very High Very High Very High
ketamine 6 99.74 Very High Very High Very High
opioid receptor 8 99.48 Very High Very High Very High
noradrenaline 16 97.72 Very High Very High Very High
Autonomic response 1 95.04 Very High Very High Very High
anesthesia 3 93.40 High High
Opioid 3 92.36 High High
depression 4 89.28 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 72 100.00 Very High Very High Very High
Autonomic Nervous System Disease 26 100.00 Very High Very High Very High
Poisoning 45 96.00 Very High Very High Very High
Pressure And Volume Under Development 1 95.28 Very High Very High Very High
Hypotension 10 93.20 High High
Depression 4 89.28 High High
Disease 4 88.80 High High
Parkinson's Disease 1 79.80 Quite High
Pain 2 73.76 Quite High
Opiate Addiction 1 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether S(+)-ketamine decreases MSA in a similar manner as the racemate is not known.
Negative_regulation (decreases) of MSA associated with ketamine and multiple system atrophy
1) Confidence 0.38 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11176089 Disease Relevance 0.27 Pain Relevance 0.44
Intra-arterial blood pressure recordings showed that MSA occurred at pressure levels normally associated with total inhibition of MSA, and that an inverse linear relationship between diastolic blood pressure and MSA at rest was abolished during the ice water immersion.
Negative_regulation (inhibition) of MSA in blood associated with multiple system atrophy
2) Confidence 0.38 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2596327 Disease Relevance 1.14 Pain Relevance 0.14
We previously demonstrated that chronic mu-opioid receptor stimulation by methadone decreases resting muscle sympathetic activity (MSA).
Negative_regulation (decreases) of MSA in sympathetic associated with methadone, opioid receptor and multiple system atrophy
3) Confidence 0.25 Published 2002 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 12198322 Disease Relevance 0.53 Pain Relevance 0.68
AAPCC = American Association of Poison Control Centers; ACLS = advanced cardiac life support; CPB = cardiopulmonary bypass; ECLS = extracorporeal life support; ECMO = extracorporeal membrane oxygenation; IABP = intra-aortic balloon pump; MSA = membrane stabilising activity; SSRI = selective serotonin reuptake inhibitor.


Negative_regulation (inhibitor) of MSA associated with multiple system atrophy, ssri and poisoning
4) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2206443 Disease Relevance 0.39 Pain Relevance 0.13
This report is the first study to show that Hr-QoL is significantly impaired in MSA.
Negative_regulation (impaired) of MSA associated with multiple system atrophy
5) Confidence 0.02 Published 2006 Journal Mov. Disord. Section Abstract Doc Link 16502399 Disease Relevance 1.26 Pain Relevance 0.18
Clonidine infusion reduces BP and HR in both MSA and PAF groups but to a greater extent in MSA patients.
Negative_regulation (reduces) of MSA associated with autonomic nervous system disease, multiple system atrophy and clonidine
6) Confidence 0.01 Published 2006 Journal Mov. Disord. Section Abstract Doc Link 16404729 Disease Relevance 1.89 Pain Relevance 1.45
MSA and PAF patients showed reduction in HR after clonidine administration, although this finding was significantly greater in MSA than in PAF patients.
Negative_regulation (reduction) of MSA associated with autonomic nervous system disease, multiple system atrophy and clonidine
7) Confidence 0.01 Published 2006 Journal Mov. Disord. Section Abstract Doc Link 16404729 Disease Relevance 1.77 Pain Relevance 1.40

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