INT273171

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDE4A, IL8) intracellular (IL8) cytoplasm (PDE4A)
cytosol (PDE4A) extracellular space (IL8) extracellular region (IL8)
Anatomy Link Frequency
epithelial cells 1
PDE4A (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 99.86 Very High Very High Very High
fibrosis 6 87.24 High High
cytokine 8 61.44 Quite High
agonist 5 37.60 Quite Low
Inflammation 29 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 99.66 Very High Very High Very High
Emphysema 8 87.80 High High
Fibrosis 6 87.24 High High
Pulmonary Disease 55 80.88 Quite High
Disease 18 60.00 Quite High
Nicotine Addiction 10 39.40 Quite Low
Vomiting 9 5.00 Very Low Very Low Very Low
Asthma 5 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of the pro-inflammatory mediators PGE2, IL-8 and 15-HETE from isolated epithelial cells was unaffected by the PDE4 inhibitors rolipram and roflumilast (Dent et al 1998; Fuhrmann et al 1999).
PDE4 Neg (unaffected) Regulation (unaffected) of IL-8 in epithelial cells associated with inflammatory mediators
1) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.53 Pain Relevance 0.15

General Comments

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