INT273172

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDE4A, CD4) plasma membrane (PDE4A, CD4) cytosol (PDE4A)
cell adhesion (CD4) nucleus (PDE4A) enzyme binding (CD4)
Anatomy Link Frequency
lymphocytes 3
PDE4A (Homo sapiens)
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammation 29 83.36 Quite High
Potency 1 58.80 Quite High
adenocard 2 44.04 Quite Low
chemokine 3 32.32 Quite Low
Inflammatory mediators 2 31.40 Quite Low
cINOD 8 21.92 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 94.68 High High
INFLAMMATION 40 83.36 Quite High
Pulmonary Disease 55 79.56 Quite High
Disease 18 34.44 Quite Low
Nicotine Addiction 10 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low
Emphysema 8 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Asthma 5 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, PDE4 inhibitors including roflumilast suppress the proliferation and cytokine release from CD4+, CD8+ lymphocytes (Hatzelmann and Schudt 2001; Landells et al 2001; Smith et al 2004) that may involve inhibition of several intracellular signalling pathways including activation of NF-?
Negative_regulation (inhibitors) of PDE4 in lymphocytes Negative_regulation (suppress) of Localization (release) of CD4 in lymphocytes associated with cytokine
1) Confidence 0.11 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.74 Pain Relevance 0.37

General Comments

This test has worked.

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