INT273175

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) molecular_function (Elane) cellular_component (Elane)
biological_process (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 2
Elane (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 29 95.52 Very High Very High Very High
cytokine 8 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 95.52 Very High Very High Very High
Pulmonary Disease 55 84.24 Quite High
Disease 18 5.00 Very Low Very Low Very Low
Nicotine Addiction 10 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low
Emphysema 8 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Asthma 5 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By week 4 roflumilast had significantly reduced the number of neutrophils and eosinophils (38% and 50%, respectively) and furthermore, there was a concomitant reduction in both neutrophil elastase and IL-8 levels (Grootendorst et al 2005).
Negative_regulation (reduction) of Gene_expression (levels) of neutrophil elastase in neutrophil
1) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.71 Pain Relevance 0.29

General Comments

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