INT273175

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.71 Pain Relevance 0.29

peptidase activity (Elane) molecular_function (Elane) cellular_component (Elane) biological_process (Elane) cytoplasm (Elane)

Anatomy Link Frequency neutrophil 2 Elane (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 29 95.52 cytokine 8 5.00 cINOD 8 5.00 fibrosis 6 5.00 agonist 5 5.00 chemokine 3 5.00 adenocard 2 5.00 Inflammatory mediators 2 5.00 Inflammatory response 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 40 95.52 Pulmonary Disease 55 84.24 Disease 18 5.00 Nicotine Addiction 10 5.00 Vomiting 9 5.00 Emphysema 8 5.00 Fibrosis 6 5.00 Asthma 5 5.00 Diarrhoea 4 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By week 4 roflumilast had significantly reduced the number of neutrophils and eosinophils (38% and 50%, respectively) and furthermore, there was a concomitant reduction in both neutrophil elastase and IL-8 levels (Grootendorst et al 2005).

Negative_regulation (reduction) of Gene_expression (levels) of neutrophil elastase in neutrophil

1) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.71 Pain Relevance 0.29

General Comments

This test has worked.