INT273179

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4D) signal transduction (PDE4D) cytoskeleton (PDE4D)
microtubule organizing center (PDE4D) cytoplasm (PDE4D)
Anatomy Link Frequency
nucleus 2
PDE4D (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 87 98.76 Very High Very High Very High
cINOD 24 98.60 Very High Very High Very High
substance P 3 97.64 Very High Very High Very High
fibrosis 18 34.04 Quite Low
Bioavailability 3 33.92 Quite Low
cytokine 24 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 120 98.76 Very High Very High Very High
Vomiting 27 87.28 High High
Diarrhoea 12 74.56 Quite High
Pulmonary Disease 165 71.12 Quite High
Asthma 15 35.80 Quite Low
Hypertrophy 3 34.68 Quite Low
Fibrosis 18 34.04 Quite Low
Disease 54 5.00 Very Low Very Low Very Low
Nicotine Addiction 30 5.00 Very Low Very Low Very Low
Emphysema 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both PDE4B and PDE4D are found within the nucleus tractis solitaris in man and rodents (Takahashi et al 1999; Cherry and Davis 1999; Perez-Torres et al 2000) whilst studies in the squirrel monkey have only demonstrated PDE4D in the area postrema with many neurones also positive for substance P (Lamontagne et al 2001).
Localization (found) of PDE4D in nucleus associated with substance p
1) Confidence 0.34 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.61 Pain Relevance 0.14
Since PDE4B and not PDE4D appear to play an important role in neutrophilic inflammation (Jin and Conti 2002), suggests that PDE4 inhibitors with low selectivity for PDE4D could prove to be novel nonemetic anti-inflammatory drugs (Lamontagne et al 2001).
Localization (selectivity) of PDE4D associated with inflammation and cinod
2) Confidence 0.32 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.67 Pain Relevance 0.19
Both PDE4B and PDE4D are found within the nucleus tractis solitaris in man and rodents (Takahashi et al 1999; Cherry and Davis 1999; Perez-Torres et al 2000) whilst studies in the squirrel monkey have only demonstrated PDE4D in the area postrema with many neurones also positive for substance P (Lamontagne et al 2001).
Spec (found) Localization (found) of PDE4D in nucleus associated with substance p
3) Confidence 0.28 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.72 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox