INT273181

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4D) signal transduction (PDE4D) cytoskeleton (PDE4D)
microtubule organizing center (PDE4D) cytoplasm (PDE4D)
PDE4D (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 99.16 Very High Very High Very High
cINOD 8 98.60 Very High Very High Very High
substance P 1 93.80 High High
Bioavailability 1 33.92 Quite Low
fibrosis 6 16.68 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 99.16 Very High Very High Very High
Vomiting 9 87.28 High High
Diarrhoea 4 57.20 Quite High
Pulmonary Disease 55 53.76 Quite High
Asthma 5 18.44 Low Low
Hypertrophy 1 17.32 Low Low
Fibrosis 6 16.68 Low Low
Disease 18 5.00 Very Low Very Low Very Low
Nicotine Addiction 10 5.00 Very Low Very Low Very Low
Emphysema 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since PDE4B and not PDE4D appear to play an important role in neutrophilic inflammation (Jin and Conti 2002), suggests that PDE4 inhibitors with low selectivity for PDE4D could prove to be novel nonemetic anti-inflammatory drugs (Lamontagne et al 2001).
Negative_regulation (inhibitors) of Localization (selectivity) of PDE4D associated with inflammation and cinod
1) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.68 Pain Relevance 0.20

General Comments

This test has worked.

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