INT273185

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PDE4A) cytosol (PDE4A) signal transduction (PDE4A)
peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
alveolar macrophages 2
PDE4A (Homo sapiens)
Mmp12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 8 94.92 High High
fibrosis 6 62.56 Quite High
Inflammatory mediators 2 38.72 Quite Low
Inflammation 29 19.36 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emphysema 8 96.44 Very High Very High Very High
Nicotine Addiction 10 72.88 Quite High
Pulmonary Disease 55 66.80 Quite High
Fibrosis 6 62.56 Quite High
Disease 18 61.48 Quite High
INFLAMMATION 40 38.72 Quite Low
Vomiting 9 5.00 Very Low Very Low Very Low
Asthma 5 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are required to determine the precise role of PDE4 in modulating MMP12 synthesis and release from alveolar macrophages.
PDE4 Spec (determine) Regulation (role) of Gene_expression (synthesis) of MMP12 in alveolar macrophages
1) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.57 Pain Relevance 0.13

General Comments

This test has worked.

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