INT2732

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2011
Negated 2
Speculated 4
Reported most in Abstract
Documents 74
Total Number 83
Disease Relevance 24.57
Pain Relevance 33.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VIP)
Anatomy Link Frequency
tear 4
ascending colon 2
veins 2
plasma 2
brain 2
VIP (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 399 100.00 Very High Very High Very High
Neuropeptide 271 100.00 Very High Very High Very High
Calcitonin gene-related peptide 112 100.00 Very High Very High Very High
Enkephalin 58 100.00 Very High Very High Very High
Somatostatin 48 100.00 Very High Very High Very High
qutenza 36 100.00 Very High Very High Very High
Cholecystokinin 12 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 28 100.00 Very High Very High Very High
Rheumatoid Arthritis 32 99.92 Very High Very High Very High
Hypersensitivity 229 99.48 Very High Very High Very High
Somatostatinoma 4 99.44 Very High Very High Very High
Cancer 80 99.36 Very High Very High Very High
Arthritis 5 99.12 Very High Very High Very High
Headache 49 99.08 Very High Very High Very High
Infection 155 99.06 Very High Very High Very High
Dengue 129 98.86 Very High Very High Very High
Neuroblastoma 10 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of both VIP binding sites on fetal vascularization and VIP-induced adenylate cyclase activation would seem to suggest a regulatory role of the peptide on fetoplacental blood flow.
Gene_expression (presence) of VIP in blood
1) Confidence 0.78 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2829291 Disease Relevance 0 Pain Relevance 0.10
Since these cells are also sensitive to cAMP stimulation by vasoactive intestinal peptide (VIP), we have tested the effects of RA on VIP receptor expression and function.
Gene_expression (expression) of VIP associated with rheumatoid arthritis
2) Confidence 0.78 Published 1989 Journal FEBS Lett. Section Abstract Doc Link 2546814 Disease Relevance 0.71 Pain Relevance 0.09
Retinoic acid enhances VIP receptor expression and responsiveness in human neuroblastoma cell, SH-SY5Y.
Gene_expression (expression) of VIP in SH-SY5Y associated with neuroblastoma
3) Confidence 0.78 Published 1989 Journal FEBS Lett. Section Title Doc Link 2546814 Disease Relevance 0.73 Pain Relevance 0.09
Neuron specific enolase (NSE), c-Fos, vasoactive intestinal peptide (VIP) and substance P (SP) were detected using immunohistochemical methods.
Gene_expression (detected) of vasoactive intestinal peptide in Neuron associated with substance p
4) Confidence 0.77 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16828227 Disease Relevance 0 Pain Relevance 0.23
Neuron specific enolase (NSE), c-Fos, vasoactive intestinal peptide (VIP) and substance P (SP) were detected using immunohistochemical methods.
Gene_expression (detected) of VIP in Neuron associated with substance p
5) Confidence 0.77 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16828227 Disease Relevance 0 Pain Relevance 0.23
In half of our cases additional production of insulin, VIP or even calcitonin in smaller amounts was found.
Gene_expression (production) of VIP
6) Confidence 0.75 Published 1986 Journal Virchows Arch A Pathol Anat Histopathol Section Abstract Doc Link 2869609 Disease Relevance 1.70 Pain Relevance 0.12
Immune system cells can produce neurologically active peptides including ACTH, CRF, growth hormone, thyrotropin, prolactin, human chorionic gonadotropin, endorphin, enkephalins, substance P, somatostatin and VIP.
Gene_expression (produce) of VIP in Immune system associated with somatostatin, enkephalin and substance p
7) Confidence 0.75 Published 1996 Journal Immunol. Res. Section Abstract Doc Link 8988397 Disease Relevance 0.42 Pain Relevance 0.45
In addition, expression of some neuropeptides such as vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), and substance P in the human salivary gland epithelium during the gestational period was observed, whereas the other polypeptides examined, including glucagon, cholecystokinin (CCK), Leu-enkephalin, and calcitonin were absent.
Gene_expression (expression) of VIP in salivary gland epithelium associated with somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
8) Confidence 0.75 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.06 Pain Relevance 0.40
Using immunocytochemical techniques, we show that substance P-, enkephalin- (leu-enkephalin, metenkephalin), and somatostatin- like immunoreactivities are expressed in subpopulations of neurones grown in vitro, whereas VIP (vasoactive intestinal polypeptide) is not detected under the same conditions.
Neg (not) Gene_expression (detected) of VIP associated with somatostatin, enkephalin and substance p
9) Confidence 0.75 Published 1989 Journal Development Section Abstract Doc Link 2482164 Disease Relevance 0 Pain Relevance 0.36
Both dentitions showed significant increases in CGRP, SP, VIP and NPY expression with caries progression.
Gene_expression (expression) of VIP in dentitions associated with substance p and calcitonin gene-related peptide
10) Confidence 0.69 Published 2002 Journal Arch. Oral Biol. Section Abstract Doc Link 12015218 Disease Relevance 0 Pain Relevance 0.81
In line with this hypothesis, an increase of SP tear and plasma levels and an altered VIP and SP expression in the conjunctiva have been described in patients with vernal keratoconjunctivitis (VKC), a severe ocular allergic disease mainly affecting young boys [23-25].
Gene_expression (expression) of VIP in conjunctiva associated with conjunctiva disease, hypersensitivity, disease and substance p
11) Confidence 0.68 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.49 Pain Relevance 0.49
The presence of vasoactive intestinal peptide (VIP) binding sites and the adenylate cyclase activity in response to VIP were examined in the human term placenta.
Spec (examined) Gene_expression (presence) of VIP in placenta
12) Confidence 0.67 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2829291 Disease Relevance 0 Pain Relevance 0
[Somatostatin and opioids, secretin and VIP--protectors of the mucosa?].
Gene_expression (--protectors) of VIP associated with somatostatin and opioid
13) Confidence 0.65 Published 1987 Journal Z Gastroenterol Section Title Doc Link 2889300 Disease Relevance 0.08 Pain Relevance 0.52
[Somatostatin and opioids, secretin and VIP--protectors of the mucosa?].
Gene_expression (opioids) of VIP associated with somatostatin and opioid
14) Confidence 0.65 Published 1987 Journal Z Gastroenterol Section Title Doc Link 2889300 Disease Relevance 0.08 Pain Relevance 0.52
Using immunohistochemical staining, the histological changes and the presence of neuropeptides (enkephalin and VIP) in the carotid body have been investigated in medico-legal autopsy cases, especially asphyxia cases.
Gene_expression (presence) of VIP in carotid body associated with asphyxia, neuropeptide and enkephalin
15) Confidence 0.65 Published 1994 Journal Int. J. Legal Med. Section Abstract Doc Link 7947333 Disease Relevance 0.10 Pain Relevance 0.15
The distribution of calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) was examined in the human temporomandibular articular disk using an indirect immunofluorescent method.
Spec (examined) Gene_expression (distribution) of VIP in articular associated with neuropeptide, substance p and calcitonin gene-related peptide
16) Confidence 0.65 Published 1999 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 10436328 Disease Relevance 0.07 Pain Relevance 0.46
Samples were assayed for calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), substance P and neuropeptide Y.
Gene_expression (assayed) of VIP associated with neuropeptide, substance p and calcitonin gene-related peptide
17) Confidence 0.65 Published 1994 Journal Brain Section Abstract Doc Link 7518321 Disease Relevance 0.61 Pain Relevance 1.29
The semiquantitative mean densities (+/- SD) of periacinar NPY, VIP and GAL fibres expressed as a percentage of the total protein gene product (PGP) 9.5 immunoreactive fibres were 75.62 +/- 7.25%, 70.52 +/- 9.33% and 41.76 +/- 5.45%, respectively, whereas those of substance P (SP), calcitonin gene-related peptide (CGRP) and FMRF amide (FMRF) fibres were below 10%.
Gene_expression (expressed) of VIP associated with calcitonin gene-related peptide and substance p
18) Confidence 0.64 Published 1997 Journal Histochem. J. Section Abstract Doc Link 9279556 Disease Relevance 0 Pain Relevance 0.42
Immunohistochemical staining has revealed the expression of five functional domains of the VIP precursor throughout the female human genital tract in neuronal elements closely related to the epithelial lining, perivascular tissue, and non-vascular smooth muscle [43].
Gene_expression (expression) of VIP precursor in neuronal
19) Confidence 0.63 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0.06 Pain Relevance 0.19
Salivary levels of CGRP and VIP in rhinosinusitis and migraine patients.
Gene_expression (levels) of VIP associated with migraine and neuropeptide
20) Confidence 0.60 Published 2006 Journal Headache Section Title Doc Link 16412148 Disease Relevance 0.19 Pain Relevance 0.33

General Comments

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