INT273218

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.06
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
spike 2
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 6 96.00 Very High Very High Very High
Neuronal excitability 51 90.48 High High
Pyramidal cell 3 89.16 High High
Hippocampus 18 87.08 High High
nMDA receptor 3 81.04 Quite High
hyperexcitability 9 80.48 Quite High
antagonist 15 46.40 Quite Low
Central nervous system 3 12.16 Low Low
depression 24 12.04 Low Low
anticonvulsant 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 204 100.00 Very High Very High Very High
Epilepsy 48 99.08 Very High Very High Very High
Shock 30 96.44 Very High Very High Very High
Status Epilepticus 21 95.32 Very High Very High Very High
Malformations Of Cortical Development 6 92.24 High High
Targeted Disruption 231 89.36 High High
Sclerosis 6 79.04 Quite High
Death 12 58.00 Quite High
Anaerobic Bacterial Infections 24 47.12 Quite Low
Tremor 3 29.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic loss of Cdk5 reduced threshold for epileptiform population-spike activity
Negative_regulation (loss) of Negative_regulation (reduced) of Cdk5 in spike
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.40 Pain Relevance 0.16
Given that loss of Cdk5 led to increases in acoustic startle reactivity, we examined whether loss of Cdk5 reduced the susceptibility to audiogenic seizures.
Spec (whether) Negative_regulation (reduced) of Spec (whether) Negative_regulation (loss) of Cdk5 associated with epilepsy
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.33 Pain Relevance 0.05
Chronic loss of Cdk5 is associated with both seizures and reduced levels of p25.
Negative_regulation (reduced) of Negative_regulation (loss) of Cdk5 associated with convulsion
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.34 Pain Relevance 0.17

General Comments

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