INT273226

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neurons 2
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 15 92.96 High High
antagonist 6 89.36 High High
Migraine 18 50.00 Quite Low
Neurotransmitter 4 44.08 Quite Low
Neuronal excitability 18 17.84 Low Low
Pain 18 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Trigeminal ganglion neurons 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 8 93.04 High High
Depression 15 92.96 High High
Targeted Disruption 80 79.68 Quite High
Ganglion Cysts 11 50.00 Quite Low
Migraine With Aura 5 50.00 Quite Low
Convulsion 68 15.20 Low Low
Pain 19 5.00 Very Low Very Low Very Low
Epilepsy 19 5.00 Very Low Very Low Very Low
Migraine Disorders 13 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditional loss of Cdk5 leads to an enhancement in CA1 hippocampal post-tetanic potentiation
Negative_regulation (loss) of Gene_expression (leads) of Cdk5
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.79 Pain Relevance 0.17
Western blotting of membrane fractions indicated a significant overall decrease of Cdk5 expression in lysates from KI ganglia (0.7 ± 0.025 fold change versus WT; n = 4, p = 0.04; Fig. 6A) together with lower P2X3/Cdk5 co-immunoprecipitation (0.8 ± 0.02 fold change in KI versus WT; n = 3, p = 0.03; Fig. 6B) despite analogous levels of total Cdk5 expression (see Fig. 6A), suggesting a different compartmentalisation of this molecules in KI neurons.
Negative_regulation (decrease) of Gene_expression (expression) of Cdk5 in neurons
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

General Comments

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