INT273230

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.48
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Cdk5r1) plasma membrane (Cdk5r1) nucleus (Cdk5r1)
embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1)
Anatomy Link Frequency
hippocampus 1
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 97.12 Very High Very High Very High
Neuronal excitability 68 95.64 Very High Very High Very High
Pyramidal cell 4 95.20 Very High Very High Very High
anticonvulsant 12 19.28 Low Low
depression 32 5.00 Very Low Very Low Very Low
antagonist 20 5.00 Very Low Very Low Very Low
hyperexcitability 12 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 272 99.90 Very High Very High Very High
Targeted Disruption 308 96.56 Very High Very High Very High
Sclerosis 8 95.72 Very High Very High Very High
Malformations Of Cortical Development 8 94.48 High High
Shock 40 94.44 High High
Status Epilepticus 28 93.32 High High
Epilepsy 64 77.72 Quite High
Drug Induced Neurotoxicity 4 64.96 Quite High
Death 16 54.24 Quite High
Neurological Disease 4 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term, but not acute, loss of Cdk5 led to decreased p25 levels, suggesting that Cdk5/p25 may be activated as a homeostatic mechanism to attenuate epileptiform activity.
Negative_regulation (decreased) of p25
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695674 Disease Relevance 0.41 Pain Relevance 0.08
Mice lacking p35 also display abnormal morphological and functional organization of the hippocampus, dysplastic hippocampi, heterotopic pyramidal cells, and granule cell dispersion and may serve as a model for cortical dysplasia [29], [57].
Negative_regulation (lacking) of p35 in hippocampus associated with malformations of cortical development, pyramidal cell and hippocampus
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.57 Pain Relevance 0.12
Chronic loss of Cdk5 is associated with both seizures and reduced levels of p25.
Negative_regulation (reduced) of p25 associated with convulsion
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.32 Pain Relevance 0.17
Loss of Cdk5 increases excitability and leads to seizures, which corresponds with decreased levels of p25.
Negative_regulation (decreased) of p25 associated with convulsion
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.18 Pain Relevance 0.16

General Comments

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