INT273234

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprs) embryo development (Cdk5) cytoplasm (Cdk5)
cytosol (Cdk5) nucleocytoplasmic transport (Cdk5) cell death (Cdk5)
Cdk5 (Mus musculus)
Ptprs (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 92.96 High High
depression 16 85.12 High High
Neurotransmitter 2 67.04 Quite High
Neuronal excitability 34 63.36 Quite High
Hippocampus 12 29.80 Quite Low
nMDA receptor 2 23.92 Low Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaerobic Bacterial Infections 16 98.84 Very High Very High Very High
Targeted Disruption 154 96.00 Very High Very High Very High
Depression 16 85.12 High High
Convulsion 136 60.56 Quite High
Shock 20 17.64 Low Low
Epilepsy 32 5.00 Very Low Very Low Very Low
Status Epilepticus 14 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Malformations Of Cortical Development 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the detailed LTP analyses, we find that loss of Cdk5 also leads to an NMDAR-independent enhancement in PTP, a presynaptic form of short-term plasticity.
Negative_regulation (loss) of Cdk5 Neg (independent) Positive_regulation (enhancement) of PTP
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.51 Pain Relevance 0.14
Conditional loss of Cdk5 led to an enhancement in PTP following a either a 100 Hz tetanus (Figure 2C) or TBS [7].
Negative_regulation (loss) of Cdk5 Positive_regulation (enhancement) of PTP associated with anaerobic bacterial infections
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.75 Pain Relevance 0.20

General Comments

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