INT273237

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5, Grin2b) plasma membrane (Cdk5, Grin2b) transport (Grin2b)
cytoplasm (Cdk5) cytosol (Cdk5) nucleocytoplasmic transport (Cdk5)
Cdk5 (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 12 87.52 High High
addiction 2 84.44 Quite High
anticonvulsant 6 77.44 Quite High
Neuronal excitability 34 68.48 Quite High
Pyramidal cell 2 41.28 Quite Low
depression 16 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 154 99.12 Very High Very High Very High
Death 8 96.84 Very High Very High Very High
Drug Induced Neurotoxicity 2 91.80 High High
Convulsion 136 90.40 High High
Disease 4 82.44 Quite High
Neurodegenerative Disease 2 81.28 Quite High
Pathologic Processes 2 73.56 Quite High
Cognitive Disorder 2 63.44 Quite High
Shock 20 48.56 Quite Low
Status Epilepticus 14 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed that Cdk5 facilitates calpain-mediated degradation of the NR2B NMDAR subunit [7].
Cdk5 Positive_regulation (facilitates) of Protein_catabolism (degradation) of NR2B NMDAR subunit
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.94 Pain Relevance 0.10
Cdk5 was shown to facilitate the calpain-mediated degradation of NR2B upon activation of NMDARs.
Cdk5 Positive_regulation (facilitate) of Protein_catabolism (degradation) of NR2B
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.37 Pain Relevance 0.12

General Comments

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