INT27325

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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 15
Total Number 22
Disease Relevance 13.69
Pain Relevance 6.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
plasma 2
lymphocytes 2
macrophages 1
colon 1
spinal cord 1
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 4 100.00 Very High Very High Very High
Crohn's disease 29 99.88 Very High Very High Very High
Spinal cord 12 99.84 Very High Very High Very High
spastic colon 740 99.80 Very High Very High Very High
Sciatic nerve 2 99.74 Very High Very High Very High
agonist 16 99.34 Very High Very High Very High
tetrodotoxin 2 99.24 Very High Very High Very High
Clonidine 3 98.74 Very High Very High Very High
Cholecystokinin 3 97.64 Very High Very High Very High
Root ganglion neuron 1 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

882 99.96 Very High Very High Very High
Disease 49 99.88 Very High Very High Very High
Frailty 12 99.84 Very High Very High Very High
Shock 5 99.36 Very High Very High Very High
Congenital Anomalies 11 98.08 Very High Very High Very High
Ganglion Cysts 1 97.04 Very High Very High Very High
Enteritis 88 95.96 Very High Very High Very High
Enterocolitis 16 90.64 High High
Neuropathic Pain 1 88.32 High High
INFLAMMATION 117 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine (10(-7) M), an alpha2-agonist, induced a moderate and delayed increase of GLP-1 and PYY but abolished the isoproterenol-induced peptide secretion.
Positive_regulation (increase) of PYY associated with agonist and clonidine
1) Confidence 0.62 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.26
Increase of PYY has previously been reported in rat colon by SCFA [60].
Positive_regulation (Increase) of PYY in colon
2) Confidence 0.58 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2311291 Disease Relevance 0 Pain Relevance 0.05
These results suggest that two mechanisms at least contribute to PYY release in the rat.
Positive_regulation (contribute) of PYY
3) Confidence 0.50 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Because terbutaline but not dobutamine or BRL 37,344 (10(-5) M) induced significant GLP-1 and PYY secretions (135+/-30 and 305+/-39 fmol/8 min respectively), isoproterenol-induced secretions are suggested to result mainly from stimulation of the beta2-isoreceptor type.
Neg (not) Positive_regulation (induced) of PYY
4) Confidence 0.45 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.24
General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.
Positive_regulation (induced) of PYY
5) Confidence 0.45 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.12
Tetrodotoxin blockade had no effect on release of PYY stimulated by 10 mM DCA.
Positive_regulation (stimulated) of PYY associated with tetrodotoxin
6) Confidence 0.41 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2596607 Disease Relevance 0 Pain Relevance 0.21
In conclusion, massive small bowel resection is a useful model to induce hyper-PYY-emia in rats.
Positive_regulation (induce) of PYY in bowel
7) Confidence 0.37 Published 1998 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 9607398 Disease Relevance 0 Pain Relevance 0.24
During early shock (S3), significant (10- to 30-fold) increases in adrenal secretion of all catecholamines, ME, NT, NPY, and PYY occurred, while VIP and PYY were significantly released into the PV, and two- to tenfold increases in femoral artery catecholamine and ME levels were observed.
Positive_regulation (increases) of PYY in femoral artery associated with catecholamine and shock
8) Confidence 0.21 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3214933 Disease Relevance 0.44 Pain Relevance 0.70
The postprandial PYY response was significantly increased in hypersensitive compared to normosensitive patients (215+/-135 versus 162+/-169 pM, p=0.048).
Positive_regulation (increased) of PYY
9) Confidence 0.11 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16484122 Disease Relevance 0 Pain Relevance 0
It has been shown that patients with Crohn's disease have elevated serum levels of PYY [14], which could be a possible explanation for upper gastrointestinal motility disturbance in these patients.
Positive_regulation (elevated) of PYY in upper associated with crohn's disease and disease
10) Confidence 0.11 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1838914 Disease Relevance 0.85 Pain Relevance 0.37
PYY inhibits intestinal motility and increases postprandial colonic absorption of water and electrolyte.29 Postprandial increase in plasma PYY levels was consistent with the increase of PYY containing cell numbers after total colectomy.30 Mucosa can be destroyed by major surgery or severe enteritis.
Positive_regulation (increase) of PYY in plasma associated with enteritis
11) Confidence 0.07 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799963 Disease Relevance 0.41 Pain Relevance 0.55
Partial sciatic nerve transection induced tyrosine hydroxidase immunoreactive axon sprouting around both injured and spared dorsal root ganglion neurons which project to the gracile nucleus in middle-aged rats.
Positive_regulation (induced) of tyrosine hydroxidase in sciatic nerve associated with ganglion cysts, root ganglion neuron and sciatic nerve
12) Confidence 0.06 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10568513 Disease Relevance 0.19 Pain Relevance 0.23
In PI-IBS, 5-HT containing EC cells tended to increase and PYY containing EC cells, CD8 lymphocytes, mast cells, and CD68+ macrophages were increased compared to non PI-IBS (p < 0.05).
Positive_regulation (increase) of PYY in mast cells
13) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2799963 Disease Relevance 0.54 Pain Relevance 0
Most of 5-HT is found in enterochromaffin cells which are best characterized subset of enteroendocrine cells.27 5-HT activates gastrointestinal motility through 5-HT3 or 5-HT4 receptors and induces gastric relaxation through 5-HT7 receptors.28 PYY is a gastrointestinal hormone, released from the endocrine cells which are distributed mainly in the distal ileum, colon and rectum.29 As shown in the present study, 5-HT containing EC cells were found to be increase in both groups but more in PI-IBS, whereas PYY containing EC cells were elevated only in PI-IBS group.
Positive_regulation (elevated) of PYY in enterochromaffin cells associated with spastic colon
14) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799963 Disease Relevance 0.29 Pain Relevance 0.58
In D-IBS, PYY containing EC cells, IELs, and CD3 lymphocytes were increased compared to control (p < 0.05).
Positive_regulation (increased) of PYY in lymphocytes
15) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2799963 Disease Relevance 0.68 Pain Relevance 0.03
PYY inhibits intestinal motility and increases postprandial colonic absorption of water and electrolyte.29 Postprandial increase in plasma PYY levels was consistent with the increase of PYY containing cell numbers after total colectomy.30 Mucosa can be destroyed by major surgery or severe enteritis.
Positive_regulation (increase) of PYY in plasma associated with enteritis
16) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799963 Disease Relevance 0.46 Pain Relevance 0.57
EC cells stained for only PYY was increased in D-IBS patients, compared to control.
Positive_regulation (increased) of PYY associated with spastic colon
17) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799963 Disease Relevance 0.18 Pain Relevance 1.07
Although there are many reports to reveal the increase of 5-HT containing EC cells and mast cells in IBS patients, there are also data that could not prove the relation of those cells with IBS.26,38 In our study, PYY containing EC cells, IEL, and CD3 lymphocyte in lamina propria were increased, whereas calprotectin positive macrophages were decreased in D-IBS patients.
Positive_regulation (increased) of PYY in macrophages associated with spastic colon
18) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799963 Disease Relevance 0.44 Pain Relevance 0.83
In healthy volunteers, there are postprandial increases in plasma peptide YY and motilin levels, which appear related to neural mechanisms.
Positive_regulation (increases) of peptide YY in neural
19) Confidence 0.03 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.69 Pain Relevance 0.21
Fasting peptide YY levels were not increased in spinal cord injury patients, which did not support tonic inhibition of peptide YY release.
Neg (not) Positive_regulation (increased) of peptide YY in spinal cord associated with spinal cord
20) Confidence 0.02 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.50 Pain Relevance 0.19

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