INT27326

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 1999
Negated 10
Speculated 1
Reported most in Abstract
Documents 27
Total Number 33
Disease Relevance 1.59
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
colon 10
vasculature 4
lumen 4
endocrine cells 4
ileum 2
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 4 100.00 Very High Very High Very High
substance P 8 99.84 Very High Very High Very High
Clonidine 6 99.84 Very High Very High Very High
tetrodotoxin 24 99.60 Very High Very High Very High
Cholecystokinin 6 99.20 Very High Very High Very High
agonist 41 99.10 Very High Very High Very High
Neurotransmitter 8 96.72 Very High Very High Very High
narcan 3 91.00 High High
Calcitonin gene-related peptide 2 83.20 Quite High
anesthesia 10 80.76 Quite High
Disease Link Frequency Relevance Heat
Shock 5 99.36 Very High Very High Very High
Pancreatitis 4 96.60 Very High Very High Very High
Vibrio Infection 8 92.88 High High
Injury 3 75.00 Quite High
Necrosis 3 25.00 Low Low
Pressure And Volume Under Development 2 25.00 Low Low
Hyperamylasemia 1 25.00 Low Low
Weight Gain 1 25.00 Low Low
INFLAMMATION 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urethane anaesthesia did not reduce PYY release induced by the intraduodenal meal.
Neg (not) Positive_regulation (induced) of Localization (release) of PYY
1) Confidence 0.70 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
PYY release induced by the intraduodenal meal peaked at 60min and lasted more than 120min.
Positive_regulation (induced) of Localization (release) of PYY
2) Confidence 0.70 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Further, these studies suggest that release of PYY is mediated by cAMP-dependent pathways.
Positive_regulation (mediated) of Localization (release) of PYY
3) Confidence 0.68 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 7694325 Disease Relevance 0.15 Pain Relevance 0.22
Because terbutaline but not dobutamine or BRL 37,344 (10(-5) M) induced significant GLP-1 and PYY secretions (135+/-30 and 305+/-39 fmol/8 min respectively), isoproterenol-induced secretions are suggested to result mainly from stimulation of the beta2-isoreceptor type.
Neg (not) Positive_regulation (induced) of Localization (secretions) of PYY
4) Confidence 0.62 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.24
When co-infused with 10(-6) M or 10(-7) M isoproterenol, 10(-7) M phenylephrine raised GLP-1 release to 174+/-53 and 108+/-28 fmol/8 min respectively (vs 38+/-16 and 35+/-10 fmol/8 min for isoproterenol alone, P<0.05) whereas PYY secretion was not significantly increased.
Neg (not) Positive_regulation (increased) of Localization (secretion) of PYY
5) Confidence 0.62 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.26
General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.
Positive_regulation (induced) of Localization (secretions) of PYY
6) Confidence 0.62 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.12
The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min induced a transient release of GLP-1 and PYY (integrated release over the 8 min of the peak secretion: 38+/-16 and 214+/-69 fmol for GLP-1 and PYY respectively, P<0.05).
Positive_regulation (induced) of Localization (release) of PYY associated with agonist
7) Confidence 0.62 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.16
Because PYY and enteroglucagon are both found in colonic endocrine cells, these results suggest that the release of PYY and enteroglucagon are mediated by specific secretagogues and not simply caused by noxious effects of the agonists.
Neg (not) Positive_regulation (mediated) of Localization (release) of PYY in endocrine cells associated with agonist
8) Confidence 0.50 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2596607 Disease Relevance 0 Pain Relevance 0.20
Tetrodotoxin did not modify the bombesin-induced release of PYY, GLP-1, and NT.
Positive_regulation (bombesin-induced) of Localization (release) of PYY associated with tetrodotoxin
9) Confidence 0.49 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.31
These results suggest that two mechanisms at least contribute to PYY release in the rat.
Positive_regulation (contribute) of Localization (release) of PYY
10) Confidence 0.47 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
The undigested meal induced no release of PYY over a 120-min period when administered into the colon.
Neg (no) Positive_regulation (induced) of Neg (no) Localization (release) of PYY in colon
11) Confidence 0.47 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Hexamethonium suppressed PYY release induced by the intraduodenal meal, but did not change PYY release induced by glucose or oleic acid in the colon.
Neg (not) Positive_regulation (induced) of Localization (release) of PYY in colon
12) Confidence 0.47 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Hexamethonium suppressed PYY release induced by the intraduodenal meal, but did not change PYY release induced by glucose or oleic acid in the colon.
Neg (not) Positive_regulation (change) of Localization (release) of PYY in colon
13) Confidence 0.47 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
The purpose of this study was 1) to measure the effect of graded concentrations of oleic acid and deoxycholic acid (DCA) on the release of peptide YY (PYY) and enteroglucagon and 2) to test whether DCA-stimulated release of PYY was neurally mediated by blocking neuronal conduction with tetrodotoxin.
Spec (whether) Positive_regulation (mediated) of Localization (release) of PYY in neuronal associated with tetrodotoxin
14) Confidence 0.47 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2596607 Disease Relevance 0 Pain Relevance 0.10
Similarly, bombesin (10(-7) M) induced a marked biphasic release of PYY and GLP-1.
Positive_regulation (induced) of Localization (release) of PYY
15) Confidence 0.45 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.29
The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min induced a transient release of GLP-1 and PYY (integrated release over the 8 min of the peak secretion: 38+/-16 and 214+/-69 fmol for GLP-1 and PYY respectively, P<0.05).
Positive_regulation (induced) of Localization (release) of PYY associated with agonist
16) Confidence 0.45 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.16
Short-chain fatty acids induced the release of PYY when injected into the colon, but not into the ileum.
Positive_regulation (induced) of Localization (release) of PYY in ileum
17) Confidence 0.41 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Hexamethonium suppressed PYY release induced by the intraduodenal meal, but did not change PYY release induced by glucose or oleic acid in the colon.
Positive_regulation (induced) of Localization (release) of PYY in colon
18) Confidence 0.41 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Carbachol-induced release of PYY into both lumen and vasculature was completely blocked by atropine, but not by hexamethonium.
Positive_regulation (induced) of Localization (release) of PYY in lumen
19) Confidence 0.41 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.09
Tetrodotoxin abolished carbachol-induced release of PYY into lumen and vasculature.
Positive_regulation (induced) of Localization (release) of PYY in vasculature associated with tetrodotoxin
20) Confidence 0.41 Published 1995 Journal Peptides Section Abstract Doc Link 7479339 Disease Relevance 0 Pain Relevance 0.10

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