INT273279

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.72
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myotubes 4
myocyte 2
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 97.20 Very High Very High Very High
adenocard 1 84.48 Quite High
halothane 5 72.44 Quite High
agonist 11 57.20 Quite High
Catecholamine 3 27.12 Quite Low
addiction 25 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 72 99.00 Very High Very High Very High
Renal Failure 1 97.36 Very High Very High Very High
Myoglobinuria 1 95.84 Very High Very High Very High
Malignant Hyperthermia 38 95.68 Very High Very High Very High
Hyperkalemia 1 94.40 High High
Rhabdomyolysis 1 91.88 High High
Acidosis 1 89.76 High High
Hypercapnia 1 88.32 High High
Contracture 5 83.88 Quite High
Adverse Drug Reaction 1 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our data revealed exaggerated decline in the steady-state myocyte peak shortening in response to increased stimulating frequency in APP/PS1 mice, suggesting a possibly reduced capacity in SR Ca2+ storage and release in this murine model of AD.
Spec (possibly) Negative_regulation (capacity) of Localization (release) of SR in myocyte associated with disease
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.20 Pain Relevance 0
Treatment of a crisis by early administration of dantrolene, an inhibitor of SR Ca2+ release, substantially reduces mortality.
Negative_regulation (inhibitor) of Localization (release) of SR
2) Confidence 0.05 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 1.17 Pain Relevance 0.18
In myotubes homozygous (Hom) for the R163C mutation, voltage-gated Ca2+ release from the SR was substantially reduced and shifted (?
Negative_regulation (reduced) of Localization (release) of SR in myotubes
3) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2888063 Disease Relevance 0.34 Pain Relevance 0.03
Thus, intact R163C Het or Hom myotubes may have enhanced Ca2+-induced Ca2+ release, which can compensate for a reduction in SR Ca2+ release that is directly voltage gated.
Negative_regulation (reduction) of Localization (release) of SR in myotubes
4) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0

General Comments

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