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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.69
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocyte 1
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 99.08 Very High Very High Very High
Intracerebroventricular 1 96.08 Very High Very High Very High
Cannabinoid 47 94.68 High High
cocaine 4 83.08 Quite High
Dopamine 24 77.28 Quite High
Cannabinoid receptor 8 77.28 Quite High
Serotonin 15 76.80 Quite High
Nucleus accumbens 2 74.68 Quite High
Inflammation 10 72.96 Quite High
Morphine 2 71.20 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 99.68 Very High Very High Very High
Disease 118 98.00 Very High Very High Very High
Congenital Anomalies 2 91.72 High High
Targeted Disruption 35 85.84 High High
Hypersensitivity Pneumonitis 70 78.64 Quite High
Heart Rate Under Development 2 76.56 Quite High
Hypercalcemia 7 75.24 Quite High
Pneumonia 3 72.96 Quite High
Cognitive Disorder 10 72.24 Quite High
Postmenopausal Osteoporosis 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the SOTI study at the end of the first year of treatment, there was a 49% lower risk reduction of a new vertebral fracture in the SR group than in the placebo group (incidence of 6.4% versus 12.2%; RR, 0.51; 95% CI: 0.36 to 0.74; P < 0.001), and a 52% lower risk of symptomatic fracture (3.1% versus. 6.4%; RR, 0.48; 95% CI: 0.29 to 0.80; P = 0.003).
Negative_regulation (reduction) of SR
1) Confidence 0.25 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.30 Pain Relevance 0
SR antigen was prepared from a strain of SR obtained from the American Type Culture Collection (ATCC, catalog no. 29034, Manassas, VA), which was grown in a lysogeny broth (LB) in a 55?
Negative_regulation (prepared) of SR associated with sprains and strains
2) Confidence 0.19 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.56 Pain Relevance 0.04
Several factors may contribute to the impaired mechanical function including defected contractile proteins (e.g., actin, myosin heavy chain isoform), reduced intracellular Ca2+ release, depressed SR Ca2+ load and altered myofilament Ca2+ sensitivity.
Negative_regulation (depressed) of SR
3) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.53 Pain Relevance 0.03
In addition, our data revealed exaggerated decline in the steady-state myocyte peak shortening in response to increased stimulating frequency in APP/PS1 mice, suggesting a possibly reduced capacity in SR Ca2+ storage and release in this murine model of AD.
Spec (possibly) Negative_regulation (capacity) of SR in myocyte associated with disease
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.15 Pain Relevance 0
We can hypothesize that, when SR is administered jointly with WIN, the antagonist blocks the CB1 receptor and in that way inhibits WIN action, while at the same time decreasing the cannabinoid tone and indirectly increasing the rewarding action of MDMA.
Negative_regulation (administered) of SR associated with cannabinoid and antagonist
5) Confidence 0.05 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.14 Pain Relevance 0.77

General Comments

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