INT2733

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Context Info
Confidence 0.57
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 12.12
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Tbxas1) endoplasmic reticulum (Tbxas1) molecular_function (Tbxas1)
cellular_component (Tbxas1)
Anatomy Link Frequency
platelet 3
paw 2
heart 2
egg 2
blood 1
Tbxas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 30 99.96 Very High Very High Very High
Paracetamol 8 99.84 Very High Very High Very High
dexamethasone 2 99.40 Very High Very High Very High
antagonist 42 99.24 Very High Very High Very High
tolerance 1 99.16 Very High Very High Very High
qutenza 5 99.12 Very High Very High Very High
local anesthetic 1 98.84 Very High Very High Very High
Angina 26 97.84 Very High Very High Very High
tetrodotoxin 5 97.84 Very High Very High Very High
lidocaine 1 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 99.36 Very High Very High Very High
Bacterial Infection 2 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.00 Very High Very High Very High
Burns 22 98.92 Very High Very High Very High
Pressure And Volume Under Development 10 98.76 Very High Very High Very High
Pressure Volume 2 Under Development 4 98.14 Very High Very High Very High
Stable Angina Pectoris 1 98.08 Very High Very High Very High
Disease 10 98.06 Very High Very High Very High
Cv General 3 Under Development 28 97.84 Very High Very High Very High
Pulmonary Embolism 14 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our objective was to test the effect of inhibition of thromboxane synthase versus inhibition of cyclooxygenase (COX)-1/2 on pulmonary gas exchange and heart function during simulated pulmonary embolism (PE) in the rat.
Negative_regulation (inhibition) of thromboxane synthase in heart associated with pulmonary embolism and cva
1) Confidence 0.57 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639842 Disease Relevance 0.42 Pain Relevance 0.33
Inhibition at the COX-1/2 enzyme was equally as effective as inhibition of thromboxane synthase at reducing alveolar dead space and improving heart function after PE.
Negative_regulation (inhibition) of thromboxane synthase in heart associated with cva
2) Confidence 0.57 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12639842 Disease Relevance 0.52 Pain Relevance 0.50
Failure of thromboxane synthetase inhibition to improve exercise tolerance in patients with stable angina pectoris.
Negative_regulation (inhibition) of thromboxane synthetase associated with stable angina pectoris, angina and tolerance
3) Confidence 0.48 Published 1984 Journal Int. J. Cardiol. Section Title Doc Link 6538553 Disease Relevance 0.10 Pain Relevance 0.15
Thromboxane synthetase (TxS) inhibitor OKY-046 and thromboxane-receptor antagonist AA-2414 significantly inhibited cough responses in repeatedly challenged animals.
Negative_regulation (inhibitor) of Thromboxane synthetase associated with antagonist and cough
4) Confidence 0.35 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11796690 Disease Relevance 0.69 Pain Relevance 0.18
Thromboxane synthetase (TxS) inhibitor OKY-046 and thromboxane-receptor antagonist AA-2414 significantly inhibited cough responses in repeatedly challenged animals.
Negative_regulation (inhibitor) of TxS associated with antagonist and cough
5) Confidence 0.35 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11796690 Disease Relevance 0.69 Pain Relevance 0.18
Effect of antirheumatics and inhibitors of cyclooxygenase, lipoxygenases and thromboxane synthetase on cobra venom factor rat paw edema.
Negative_regulation (inhibitors) of thromboxane synthetase in paw associated with pressure and volume under development
6) Confidence 0.29 Published 1984 Journal Biomed. Biochim. Acta Section Title Doc Link 6440543 Disease Relevance 0.20 Pain Relevance 0.18
Inhibitors of thromboxane synthesis such as the cyclooxygenase inhibitor, indomethacin, the thromboxane synthase blocker, 1-benzylimidazole, or the combined cyclooxygenase/lipoxygenase/thromboxane synthase inhibitor, sulfasalazine, inhibited the contraction evoked by egg albumin.
Negative_regulation (inhibitor) of thromboxane synthase in egg
7) Confidence 0.28 Published 1997 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 9342927 Disease Relevance 0 Pain Relevance 0.13
We studied the effect of inhibiting thromboxane synthetase, using dazmegrel, on postburn hemodynamic stability and edema formation, the latter monitored by burn tissue lymph flow.
Negative_regulation (inhibiting) of thromboxane synthetase in lymph associated with pressure and volume under development and burns
8) Confidence 0.25 Published 1989 Journal Surgery Section Abstract Doc Link 2705099 Disease Relevance 0.59 Pain Relevance 0.07
Inhibition of thromboxane synthetase accentuates hemodynamic instability and burn edema in the anesthetized sheep model.
Negative_regulation (Inhibition) of thromboxane synthetase associated with pressure and volume under development and burns
9) Confidence 0.25 Published 1989 Journal Surgery Section Title Doc Link 2705099 Disease Relevance 0.80 Pain Relevance 0.08
Of interest was that oxygen consumption was better maintained with dazmegrel postburn, even with the relative hypovolemia, indicating that postburn vasoconstriction impairs adequate O2 delivery to tissues and that thromboxane synthetase inhibition attenuates this process.
Negative_regulation (inhibition) of thromboxane synthetase associated with pressure volume 2 under development and increased venous pressure under development
10) Confidence 0.25 Published 1989 Journal Surgery Section Abstract Doc Link 2705099 Disease Relevance 0.84 Pain Relevance 0.07
Inhibitors of thromboxane synthesis such as the cyclooxygenase inhibitor, indomethacin, the thromboxane synthase blocker, 1-benzylimidazole, or the combined cyclooxygenase/lipoxygenase/thromboxane synthase inhibitor, sulfasalazine, inhibited the contraction evoked by egg albumin.
Negative_regulation (inhibitor) of thromboxane synthase in egg
11) Confidence 0.25 Published 1997 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 9342927 Disease Relevance 0 Pain Relevance 0.13
The cobra venom factor (CVF) rat paw edema was inhibited by cyclooxygenase (indomethacin, piroxicam, aspirin), lipoxygenase (BW 755c) and thromboxane synthetase (imidazole) inhibitors as well as by dexamethasone and, at high doses, by paracetamol and phenacetin.
Negative_regulation (inhibitors) of thromboxane synthetase in paw associated with aspirin, pressure and volume under development, paracetamol and dexamethasone
12) Confidence 0.21 Published 1984 Journal Biomed. Biochim. Acta Section Abstract Doc Link 6440543 Disease Relevance 0.17 Pain Relevance 0.20
In summary, MED 27 dually inhibits both thromboxane synthase and thromboxane receptors.
Negative_regulation (inhibits) of thromboxane synthase
13) Confidence 0.18 Published 1996 Journal Arzneimittelforschung Section Abstract Doc Link 8821515 Disease Relevance 0 Pain Relevance 0.39
[Effects of a thromboxane-synthetase inhibitor in patients with chronic persistent coughing and no airwayhyperresponsiveness].
Negative_regulation (inhibitor) of thromboxane-synthetase
14) Confidence 0.17 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Title Doc Link 9396248 Disease Relevance 0.08 Pain Relevance 0.11
Antiplatelet effect of a new inhibitor of thromboxane synthase and thromboxane A2 receptors.
Negative_regulation (inhibitor) of thromboxane synthase
15) Confidence 0.13 Published 1996 Journal Arzneimittelforschung Section Title Doc Link 8821515 Disease Relevance 0 Pain Relevance 0.21
Improvement in organ blood flow by inhibition of thromboxane synthetase during experimental endotoxic shock in the rat.
Negative_regulation (inhibition) of thromboxane synthetase in blood associated with bacterial infection
16) Confidence 0.12 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2425166 Disease Relevance 0.26 Pain Relevance 0.07
Previous studies have verified that L-NAME and ozagrel in the doses used in our present study effectively inhibit the activity of cerebral NO synthase and thromboxane synthase, respectively [21], [22].
Negative_regulation (inhibit) of thromboxane synthase
17) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0 Pain Relevance 0.04
The beneficial effects of ONO-1301 occurred through its long-lasting stimulation of cAMP and inhibition of thromboxane synthase [7].
Negative_regulation (inhibition) of thromboxane synthase
18) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.99 Pain Relevance 0.15
Effects of inhibitors of phospholipase A2, cyclooxygenase and thromboxane synthetase on paracetamol hepatotoxicity in the rat.
Negative_regulation (inhibitors) of thromboxane synthetase associated with paracetamol and hepatotoxicity
19) Confidence 0.09 Published 1989 Journal Eicosanoids Section Title Doc Link 2516744 Disease Relevance 0.45 Pain Relevance 0.25
Inhibitors of PLA2, cyclooxygenase and thromboxane synthetase injected i.p. 7 h after paracetamol prevented hepatotoxicity as measured by SGPT activity but did not prevent an increase in glycogen phosphorylase "a" activity.
Negative_regulation (Inhibitors) of thromboxane synthetase associated with paracetamol and hepatotoxicity
20) Confidence 0.09 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.43 Pain Relevance 0.27

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