INT273345

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde7a)
Anatomy Link Frequency
lung 2
Pde7a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 93 98.40 Very High Very High Very High
Inflammatory mediators 3 87.20 High High
chemokine 12 85.08 High High
Inflammatory response 12 69.64 Quite High
Potency 15 5.00 Very Low Very Low Very Low
Inflammatory marker 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 21 98.60 Very High Very High Very High
Targeted Disruption 15 97.28 Very High Very High Very High
INFLAMMATION 99 87.20 High High
Pulmonary Disease 57 69.96 Quite High
Asthma 12 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low
Emphysema 9 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose-dependent and sequence-specific down-regulation of PDE7A mRNA expression was also achieved following transfection with AON 7A (Figure 1C).


Gene_expression (expression) of PDE7A mRNA
1) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.32 Pain Relevance 0.08
We next wanted to determine whether inhibition of PDE4B, PDE4D and PDE7A expression in the lung would protect against lung inflammation in mice exposed to cigarette smoke.
Gene_expression (expression) of PDE7A in lung associated with inflammation and pneumonia
2) Confidence 0.65 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.65 Pain Relevance 0.22
Efficacy of locally administered PDE4B/4D and PDE7A AON against cigarette smoke-induced lung inflammation in mice, and comparison with roflumilast
Gene_expression (administered) of PDE7A in lung associated with inflammation and pneumonia
3) Confidence 0.25 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.47 Pain Relevance 0.16

General Comments

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