INT273369

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOCS3, JAK1) cytoplasm (SOCS3, JAK1) aging (SOCS3)
cytoskeleton (JAK1) nucleus (JAK1)
SOCS3 (Homo sapiens)
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 74.76 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 11 49.48 Quite Low
Hypertrophy 9 38.84 Quite Low
Disease 2 5.00 Very Low Very Low Very Low
Appetite Loss 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Muscular Atrophy 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Muscle Wasting Disease 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS3 can bind phosphotyrosines on the JAK2 receptors, physically blocking STAT3 binding, as well as biding to JAK2, directly blocking JAK kinase activity [50].
SOCS3 Negative_regulation (blocking) of JAK kinase
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

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