INT27338

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.25
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
Anatomy Link Frequency
neurons 1
body 1
neuropil 1
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 99.98 Very High Very High Very High
Opioid 3 99.78 Very High Very High Very High
Enkephalin 11 99.64 Very High Very High Very High
antagonist 1 94.64 High High
Clonidine 48 92.32 High High
substance P 6 91.40 High High
Neuropeptide 7 90.76 High High
positron emission tomography 3 88.08 High High
imagery 2 85.28 High High
Limbic system 2 84.84 Quite High
Disease Link Frequency Relevance Heat
Disease 3 100.00 Very High Very High Very High
Aging 3 86.40 High High
Poisoning 24 83.20 Quite High
Muscle Weakness 2 76.56 Quite High
Increased Venous Pressure Under Development 1 73.32 Quite High
Abdominal Pain 1 68.60 Quite High
Toxicity 4 66.16 Quite High
Vomiting 2 64.96 Quite High
Emergencies 1 63.24 Quite High
Respiratory Failure 5 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Opioid peptides, regulators of acetylcholinesterase activity].
Regulation (regulators) of acetylcholinesterase associated with enkephalin and opioid
1) Confidence 0.62 Published 1989 Journal Biull Eksp Biol Med Section Title Doc Link 2597760 Disease Relevance 0 Pain Relevance 0.48
In this clinical setting it is appropriate to examine inexpensive antidotes operating through synergistic mechanisms that are not dependent upon acetylcholinesterase reactivation.
Neg (not) Regulation (dependent) of acetylcholinesterase
2) Confidence 0.45 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.28 Pain Relevance 0.30
It is unclear whether the palliative effects of tetrahydroaminoacridine (THA) (tacrine, Cognex) on the clinical symptoms of patients affected by Alzheimer's disease (AD) are the result of its inhibitory activity on acetylcholinesterase or on other complex sites of action.
Spec (whether) Regulation (effects) of acetylcholinesterase associated with disease and palliative
3) Confidence 0.44 Published 1999 Journal Eur. J. Neurol. Section Abstract Doc Link 10210906 Disease Relevance 0.20 Pain Relevance 0.23
The main findings of this study are: 1) AChE was very abundant in the AD and was irregular or heterogeneously distributed in the AV and AM; 2) LAMP immunoreactive (ir) neuropil was present throughout the ATN and its distribution was heterogeneous in the AV and AM; 3) the ATN harbored CB-, PV- and CR-ir neurons and neuropil; and, 4) the neuropeptide analysis revealed numerous SP positive varicose fibers scattered throughout the ATN in contrast to very few ENK-ir varicose fibers.
Regulation (irregular) of AChE in neuropil associated with neuropeptide, enkephalin and substance p
4) Confidence 0.35 Published 2007 Journal J Neural Transm Section Abstract Doc Link 17308982 Disease Relevance 0 Pain Relevance 0.60
We conducted a study in the change of preshift and postshift acetylcholinesterase levels among six of his co-workers on a rainy day.
Regulation (change) of acetylcholinesterase
5) Confidence 0.27 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1240170 Disease Relevance 0.63 Pain Relevance 0.07
Additionally, it has no effect on acetylcholinesterase or any receptor system in the body.
Neg (no) Regulation (effect) of acetylcholinesterase in body
6) Confidence 0.26 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17312211 Disease Relevance 0.15 Pain Relevance 0.10
The main findings of this study are: 1) AChE was very abundant in the AD and was irregular or heterogeneously distributed in the AV and AM; 2) LAMP immunoreactive (ir) neuropil was present throughout the ATN and its distribution was heterogeneous in the AV and AM; 3) the ATN harbored CB-, PV- and CR-ir neurons and neuropil; and, 4) the neuropeptide analysis revealed numerous SP positive varicose fibers scattered throughout the ATN in contrast to very few ENK-ir varicose fibers.
Regulation (irregular) of AChE in neurons associated with neuropeptide, enkephalin and substance p
7) Confidence 0.12 Published 2007 Journal J Neural Transm Section Abstract Doc Link 17308982 Disease Relevance 0 Pain Relevance 0.60

General Comments

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