INT273393

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
muscle 1
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 33 99.16 Very High Very High Very High
Hypertrophy 27 26.00 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Appetite Loss 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Muscular Atrophy 3 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low
Muscle Wasting Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-localization of p-STAT3 with Pax7 may be due to the phosphorylation of STAT3 protein within the SCs induced by the increase in IL-6 protein observed in the SCs at T4.
Phosphorylation (phosphorylation) of SCs
1) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0
Alternatively, it is possible that changes in protein phosphorylation events within the SCs were too subtle to detect at the whole muscle level using standard western blotting techniques.
Phosphorylation (phosphorylation) of SCs in muscle
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
The timing of the appearance of p-STAT3 in the SCs is in agreement with observations made in rats demonstrating that SCs expressed phosphorylated STAT3 3 h following injury [55].
Phosphorylation (phosphorylated) of SCs associated with injury
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.27 Pain Relevance 0

General Comments

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