INT273404

Context Info Confidence 0.36 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.09 Pain Relevance 0.03

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA) nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)

PCNA (Homo sapiens)

Pain Link Frequency Relevance Heat Calcium channel 1 58.76 Hippocampus 10 5.00 cytokine 5 5.00 isoflurane 4 5.00 Central nervous system 2 5.00 anesthesia 2 5.00 withdrawal 2 5.00 Intracerebroventricular 2 5.00 Inflammation 1 5.00 local anesthetic 1 5.00

Disease Link Frequency Relevance Heat Injury 11 89.28 Sleep Disorders 162 50.00 Neurodegenerative Disease 70 50.00 Cognitive Disorder 20 50.00 Body Weight 2 14.72 Stress 14 5.00 Hypertrophy 9 5.00 Anxiety Disorder 4 5.00 Cancer 4 5.00 Hypertension 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, there was a positive correlation between the increase in IL-6 and the increase in PCNA co-localization with Pax7 early in the post-intervention time-course.

Positive_regulation (increase) of Localization (localization) of PCNA

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0.03

This same protocol was followed for proliferating cell nuclear antigen (PCNA), a co-factor for DNA polymerase and a convenient endogenous marker for newly proliferated cells, immunofluorescence using mouse anti-PCNA (1?

Positive_regulation (for) of Localization (marker) of PCNA

2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995744 Disease Relevance 0 Pain Relevance 0

This same protocol was followed for proliferating cell nuclear antigen (PCNA), a co-factor for DNA polymerase and a convenient endogenous marker for newly proliferated cells, immunofluorescence using mouse anti-PCNA (1?

Positive_regulation (for) of Localization (marker) of PCNA

3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995744 Disease Relevance 0 Pain Relevance 0

General Comments

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