INT273406

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 8.42
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
lymph node 4
muscle 2
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 45 89.00 High High
tolerance 4 31.64 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
palliative 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 554 100.00 Very High Very High Very High
Cervical Cancer 4 100.00 Very High Very High Very High
Prostate Cancer 212 99.52 Very High Very High Very High
Metastasis 86 99.40 Very High Very High Very High
Reprotox - General 1 14 98.92 Very High Very High Very High
Disease 68 92.28 High High
Carcinoma 8 75.00 Quite High
Hypertrophy 9 70.00 Quite High
Injury 11 64.28 Quite High
Apoptosis 34 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, TWIST1 expression was not increased in hormone-refractory tumors when compared to hormone-naïve samples, suggesting that TWIST1 overexpression alone may not be enough to confer hormone-refractory growth.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TWIST1 associated with cancer
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.52 Pain Relevance 0
Quantitative PCR confirmed overexpression of TWIST1 in primary PCa samples and lymph node metastasis (Fig. 5A).
Positive_regulation (overexpression) of Gene_expression (overexpression) of TWIST1 in lymph node associated with prostate cancer and metastasis
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.73 Pain Relevance 0
Furthermore, TWIST1 expression was not increased in hormone-refractory tumors when compared to hormone-naïve samples, suggesting that TWIST1 overexpression alone may not be enough to confer hormone-refractory growth.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of TWIST1 associated with cancer
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.63 Pain Relevance 0
We quantified TWIST1 expression in a panel of patient derived material, comprising 21 normal prostate samples (adjacent to cancer), 74 primary prostate tumors, of which 9 hormone-refractory samples, and 13 lymph node metastasis.
Positive_regulation (quantified) of Gene_expression (expression) of TWIST1 in lymph node associated with cancer, prostate cancer and metastasis
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.32 Pain Relevance 0
The expression of Twist, for example, has been found to be elevated in various types of cancer, including breast, prostate, and cervical cancer, with higher levels of Twist protein being detected in prostate cancer tissues of high Gleason score [38, 39].
Positive_regulation (elevated) of Gene_expression (expression) of Twist associated with cervical cancer, cancer and reprotox - general 1
5) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.00 Pain Relevance 0
The expression of Twist, for example, has been found to be elevated in various types of cancer, including breast, prostate, and cervical cancer, with higher levels of Twist protein being detected in prostate cancer tissues of high Gleason score [38, 39].
Positive_regulation (elevated) of Gene_expression (levels) of Twist associated with cervical cancer, cancer and reprotox - general 1
6) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 1.08 Pain Relevance 0
Immunohistochemical analysis of muscle cross-sections was performed for the quantification of SCs (Pax7+ cells) as well as the expression of phosphorylated STAT3, IL-6, IL-6R?
Positive_regulation (performed) of Gene_expression (quantification) of SCs in muscle
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0.04

General Comments

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