INT273441

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.13
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) mitochondrion (Vamp1) vesicle-mediated transport (Vamp1)
plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
vesicles 1
synaptic vesicles 1
Vamp1 (Mus musculus)
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 30 88.56 High High
Multiple sclerosis 5 28.88 Quite Low
Glutamate 50 5.00 Very Low Very Low Very Low
tetrodotoxin 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Pyramidal cell 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 10 66.32 Quite High
Demyelinating Disease 5 28.88 Quite Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low
Aging 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, synaptobrevin in synaptic vesicles does not readily react with syntaxin and SNAP-25 (Hu et al., 2002).
synaptobrevin Neg (not) Binding (react) of SNAP-25 in synaptic vesicles
1) Confidence 0.02 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0.03
Similar to vesicular synaptobrevin, liposomal synaptobrevin was inactive for interaction with syntaxin and SNAP-25 (Figure 7B), demonstrating that phospholipid membrane is sufficient for synaptobrevin restriction.
synaptobrevin Binding (interaction) of SNAP-25
2) Confidence 0.01 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0.06
This step is followed by synaptobrevin engagement of syntaxin/SNAP-25 resulting in SNARE assembly and an augmented pool of readily-releasable vesicles.
synaptobrevin Binding (engagement) of SNAP-25 in vesicles
3) Confidence 0.01 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0.13 Pain Relevance 0.04
Therefore synaptobrevin's ability to engage syntaxin/SNAP-25 can be analyzed through the formation of SDS-resistant SNARE complexes.
synaptobrevin Binding (engage) of SNAP-25
4) Confidence 0.01 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
In contrast, when we incorporated syntaxin/SNAP-25 into liposomes and tested SNARE assembly in the presence of a soluble part of synaptobrevin, sphingosine did not enhance the ability of this membrane-free synaptobrevin to form SNARE complex with syntaxin and SNAP-25 (Figure S4).
synaptobrevin Binding (complex) of SNAP-25
5) Confidence 0.01 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0

General Comments

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