INT273455

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Elovl4)
Anatomy Link Frequency
retinas 2
photoreceptors 2
Elovl4 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 99.98 Very High Very High Very High
Retina Disease 16 98.48 Very High Very High Very High
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore conclude that in the animal model we used, namely a transgenic mouse overexpressing mutant human ELOVL4 along with two normal mouse copies, DHA does not rescue structure or function of rod photoreceptors.



Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ELOVL4 in photoreceptors associated with targeted disruption
1) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697457 Disease Relevance 0.26 Pain Relevance 0
The results of our study show that high DHA levels in the retinas of mice overexpressing the mutated ELOVL4 transgene do not slow or prevent the retinal degeneration.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ELOVL4 in retinas associated with retina disease
2) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697457 Disease Relevance 0.26 Pain Relevance 0

General Comments

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