INT273491

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 4.29
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 99.02 Very High Very High Very High
Inflammation 2 98.82 Very High Very High Very High
cva 12 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 2 99.32 Very High Very High Very High
INFLAMMATION 2 98.82 Very High Very High Very High
Chronic Disease 2 97.94 Very High Very High Very High
Anaemia 136 97.56 Very High Very High Very High
Syndrome 2 97.36 Very High Very High Very High
Cancer 112 96.38 Very High Very High Very High
Hemorrhage 2 95.88 Very High Very High Very High
Vitamin Deficiency 2 95.16 Very High Very High Very High
Hemolysis 2 93.92 High High
Immunotherapy Of Cancer 14 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are many potential causes of anemia in a patient with cancer.1 Commonly cancer-related anemia can be attributed to the syndrome of anemia of chronic disease (ACD) which is mediated by pro-inflammatory cytokines and characterized by impaired iron utilization, reduced erythropoietin (EPO) mRNA synthesis and reduced RBC lifespan.2 This diagnosis requires exclusion of other possible causes, such as occult bleeding, iron or vitamin deficiency, autoimmune hemolysis or marrow infiltration.
Negative_regulation (reduced) of Transcription (synthesis) of erythropoietin associated with syndrome, vitamin deficiency, hemorrhage, cytokine, inflammation, anaemia, cancer, lifespan, hemolysis and chronic disease
1) Confidence 0.58 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 2.15 Pain Relevance 0.10
There are many potential causes of anemia in a patient with cancer.1 Commonly cancer-related anemia can be attributed to the syndrome of anemia of chronic disease (ACD) which is mediated by pro-inflammatory cytokines and characterized by impaired iron utilization, reduced erythropoietin (EPO) mRNA synthesis and reduced RBC lifespan.2 This diagnosis requires exclusion of other possible causes, such as occult bleeding, iron or vitamin deficiency, autoimmune hemolysis or marrow infiltration.
Negative_regulation (reduced) of Transcription (synthesis) of EPO associated with syndrome, vitamin deficiency, hemorrhage, cytokine, inflammation, anaemia, cancer, lifespan, hemolysis and chronic disease
2) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 2.15 Pain Relevance 0.10

General Comments

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