INT273509

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 2 84.12 Quite High
antagonist 44 79.28 Quite High
headache 5 68.32 Quite High
Glutamate 2 56.48 Quite High
Serotonin 8 30.92 Quite Low
chemokine 4 22.40 Low Low
Inflammation 26 10.88 Low Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 1 94.76 High High
Toxicity 2 89.84 High High
Stress 2 77.16 Quite High
Hypersensitivity 2 69.80 Quite High
Headache 5 68.32 Quite High
Vomiting 111 67.84 Quite High
Poisoning 1 66.44 Quite High
Hepatotoxicity 2 65.48 Quite High
Dizziness 2 59.68 Quite High
Constipation 3 58.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, and synergistically induced CYP1A1 expression with the typical CYP1A inducers [95,96].
Positive_regulation (induced) of Gene_expression (expression) of CYP1A2
1) Confidence 0.14 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.38 Pain Relevance 0.14
Palonosetron does not cause inhibition or induction of the main hepatic enzyme systems including CYP2D6, CYP1A2 and CYP3A4/5, so the risk of significant drug interactions is low.119 However an adverse reaction with apomorphine that presented as profound hypotension and altered consciousness has been reported, so concomitant use is contraindicated.128


Positive_regulation (including) of Gene_expression (/) of CYP1A2 associated with pressure volume 2 under development
2) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697527 Disease Relevance 0.82 Pain Relevance 0.19

General Comments

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