INT273522

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NBN) nucleolus (NBN) chromosome (NBN)
nucleus (NBN) intracellular (NBN) cell cycle (NBN)
Anatomy Link Frequency
liver 2
NBN (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 98.88 Very High Very High Very High
Hepatitis C Virus Infection 3 96.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 61 96.24 Very High Very High Very High
Liver Disease 2 94.60 High High
Cirrhosis 1 91.12 High High
Body Weight 2 57.96 Quite High
Disorders Of Creatine Metabolism 1 53.04 Quite High
Chronic Renal Failure 2 27.60 Quite Low
Hyperbilirubinemia 21 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis on these data, a dose reduction of ATV is advised for patients with moderate hepatic dysfunction.1 In contrast, in a study conducted in 58 HCV/HIV-coinfected patients with compensated liver disease, ATV Cmin did not differ significantly between patients with and without liver cirrhosis.17

Renal impairment

Negative_regulation (reduction) of Gene_expression (advised) of ATV in liver associated with liver disease, cirrhosis, acquired immune deficiency syndrome or hiv infection, hepatotoxicity and hepatitis c virus infection
1) Confidence 0.34 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.91 Pain Relevance 0

General Comments

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