INT273546

Context Info Confidence 0.46 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0

mitochondrion (Abl1) DNA binding (Abl1) cytoplasm (Abl1) cytosol (Abl1) nucleolus (Abl1) cell adhesion (Abl1)

Anatomy Link Frequency T cell 2 Abl1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 5 7.52 cva 2 5.00 Piles 1 5.00 headache 1 5.00 abdominal pain 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Philadelphia Chromosome 11 94.80 Lymphocytosis 2 80.36 Myeloid Leukemia 64 59.40 Leukemia 6 50.00 Apoptosis 7 44.64 Toxicity 8 29.36 Pressure And Volume Under Development 8 5.00 Blast Crisis 8 5.00 Pleural Effusion 4 5.00 Exanthema 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Potential mechanisms for the pathogenesis of large granular lymphocytes after dasatinib therapy include the reduction of BCR/ABL transcription by TKIs and restoration of NK cell numbers and/or functions, and direct activation or modulation of the proliferation and function of LGLs.33 However, it is still unclear whether the effect of dasatinib on NK or NK/T cell proliferation or activation is mediated via Src kinase or other unknown potential pathways involved in the proliferation and differentiation of NK or NK/T cells.33 Pharmacokinetics

Negative_regulation (reduction) of Transcription (transcription) of ABL in T cell

1) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.30 Pain Relevance 0

General Comments

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