INT273546

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abl1) DNA binding (Abl1) cytoplasm (Abl1)
cytosol (Abl1) nucleolus (Abl1) cell adhesion (Abl1)
Anatomy Link Frequency
T cell 2
Abl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 5 7.52 Low Low
cva 2 5.00 Very Low Very Low Very Low
Piles 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Philadelphia Chromosome 11 94.80 High High
Lymphocytosis 2 80.36 Quite High
Myeloid Leukemia 64 59.40 Quite High
Leukemia 6 50.00 Quite Low
Apoptosis 7 44.64 Quite Low
Toxicity 8 29.36 Quite Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Blast Crisis 8 5.00 Very Low Very Low Very Low
Pleural Effusion 4 5.00 Very Low Very Low Very Low
Exanthema 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potential mechanisms for the pathogenesis of large granular lymphocytes after dasatinib therapy include the reduction of BCR/ABL transcription by TKIs and restoration of NK cell numbers and/or functions, and direct activation or modulation of the proliferation and function of LGLs.33 However, it is still unclear whether the effect of dasatinib on NK or NK/T cell proliferation or activation is mediated via Src kinase or other unknown potential pathways involved in the proliferation and differentiation of NK or NK/T cells.33

Pharmacokinetics

Negative_regulation (reduction) of Transcription (transcription) of ABL in T cell
1) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox