INT273548

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abl1) DNA binding (Abl1) cytoplasm (Abl1)
cytosol (Abl1) nucleolus (Abl1) cell adhesion (Abl1)
Anatomy Link Frequency
platelet 2
Abl1 (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 1 47.20 Quite Low
headache 3 44.88 Quite Low
Piles 1 31.68 Quite Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 93.40 High High
Myeloid Leukemia 149 88.48 High High
Solid Tumor 1 71.12 Quite High
Toxicity 14 64.16 Quite High
Blast Crisis 12 58.92 Quite High
Recurrence 8 55.80 Quite High
Diarrhoea 4 50.24 Quite High
Leukemia 21 50.00 Quite Low
Vomiting 6 49.44 Quite Low
Appetite Loss 2 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, 162 patients were followed with mutational analysis: 26% retained a BCR-ABL mutation, 26% lost a mutation, 27% developed a mutation, and the remaining belonged to > 1 mutational category.24
Negative_regulation (retained) of ABL Binding (mutation) of
1) Confidence 0.34 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.24 Pain Relevance 0
These compounds also inhibit Bcr-Abl, Kit and platelet-derived growth factor receptor ?
Negative_regulation (inhibit) of Abl Binding (compounds) of in platelet
2) Confidence 0.17 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.64 Pain Relevance 0

General Comments

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