INT273561

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1A1, CYP3A4) endoplasmic reticulum (CYP1A1, CYP3A4) enzyme binding (CYP1A1, CYP3A4)
cytoplasm (CYP1A1, CYP3A4) oxidoreductase activity (CYP1A1, CYP3A4) mitochondrion (CYP1A1)
CYP1A1 (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 35 67.96 Quite High
headache 1 60.56 Quite High
antagonist 20 50.00 Quite Low
substance P 9 5.00 Very Low Very Low Very Low
Antiemetics 8 5.00 Very Low Very Low Very Low
trigger zone 5 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dizziness 1 61.12 Quite High
Headache 1 60.56 Quite High
Vomiting 117 50.00 Quite Low
Neutropenia 8 5.00 Very Low Very Low Very Low
Post-operative Nausea 6 5.00 Very Low Very Low Very Low
Fatigue 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Alopecia 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Granisetron is primarily metabolized by CYP3A4 with a minor contribution from CYP1A1.
CYP1A1 Binding (metabolized) of CYP3A4
1) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697542 Disease Relevance 0.12 Pain Relevance 0.15

General Comments

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