INT273617

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
plasma 2
Slc6a4 (Rattus norvegicus)
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
sSRI 2 98.00 Very High Very High Very High
fluoxetine 1 96.12 Very High Very High Very High
antagonist 17 77.60 Quite High
cva 2 26.80 Quite Low
Calcium channel 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 106 100.00 Very High Very High Very High
Hypoxia 3 100.00 Very High Very High Very High
Death 2 79.00 Quite High
Apoptosis 4 76.24 Quite High
Peripheral Arterial Disease 5 62.76 Quite High
Pulmonary Disease 3 40.64 Quite Low
Increased Venous Pressure Under Development 17 28.52 Quite Low
Cv General 3 Under Development 1 26.80 Quite Low
Systemic Sclerosis 1 10.40 Low Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Research has found that patients with PAH have increased plasma serotonin levels,118 and that over-expression of the serotonin transporter gene (SERT) increases PA pressure.119 Hypoxia and monocrotaline-induced PAH in animals has been shown to be inhibited by the selective serotonin reuptake inhibitor (SSRI), fluoxetine.120,121 So far however, studies in humans have not produced statistically significant results.122

l-Arginine

Gene_expression (expression) of serotonin transporter gene in plasma Positive_regulation (increases) of PAH associated with pulmonary hypertension, hypoxia, ssri, serotonin and fluoxetine
1) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.93 Pain Relevance 0.38

General Comments

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