INT273619

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 2
GUCY2C (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 34.16 Quite Low
withdrawal 1 22.32 Low Low
antagonist 17 5.00 Very Low Very Low Very Low
Calcium channel 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 106 100.00 Very High Very High Very High
Hypoxia 3 82.68 Quite High
Cv General 4 Under Development 9 63.48 Quite High
Syncope 3 62.64 Quite High
Acute Disease 1 61.32 Quite High
Increased Venous Pressure Under Development 17 39.68 Quite Low
Bronchopulmonary Dysplasia 1 35.68 Quite Low
Asthma 1 34.48 Quite Low
Cystic Fibrosis 1 34.16 Quite Low
Airway Obstruction 2 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide (NO) inhalation is currently among the first line treatments for post-operative pediatric pulmonary hypertension or in the child with acute severe new presentation of PAH being managed on the intensive care unit,36,37 as it reduces PA pressure rapidly.38 Inhaled NO therapy is also used acutely in persistent pulmonary hypertension of the newborn.39 The mode of action of NO is via the stimulation of guanylyl cyclase and hence increased production of cyclic guanylate monophosphate (cGMP) in pulmonary smooth muscle cells; this causes uptake of calcium into the sarcoplasmic reticulum, which then leads to muscle relaxation, reduced PA pressure and PVR, and hence increased oxygenation.
Negative_regulation (reduces) of Gene_expression (production) of guanylyl cyclase in muscle associated with pulmonary hypertension
1) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.79 Pain Relevance 0

General Comments

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