INT27366

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.29
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
eye 2
brain 2
neuromuscular junction 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 13 90.52 High High
tetrodotoxin 8 88.96 High High
Hippocampus 4 85.60 High High
agonist 3 83.44 Quite High
monoamine 7 79.96 Quite High
addiction 5 73.44 Quite High
Action potential 3 71.24 Quite High
palliative 1 70.08 Quite High
antagonist 3 62.96 Quite High
depression 4 24.56 Low Low
Disease Link Frequency Relevance Heat
Clostridium Infection 1 87.84 High High
Dementia 2 75.00 Quite High
Ganglion Cysts 1 59.12 Quite High
Depression 4 24.56 Low Low
Unconsciousness 11 5.00 Very Low Very Low Very Low
Sleep Disorders 5 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments show that uniocular injections result in a markedly decreased level of AChE activity in layer IV of the medial part of cortical area 17 contralateral to the injected eye.
Negative_regulation (decreased) of Negative_regulation (level) of AChE in eye
1) Confidence 0.43 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.06 Pain Relevance 0.54
Selective inhibition of the choline uptake system using hemicholinium III (10(5)m), which blocks non-quantal release at the neuromuscular junction, suppressed the effects of AChE inhibitors.
Negative_regulation (suppressed) of Negative_regulation (inhibitors) of AChE in neuromuscular junction
2) Confidence 0.42 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19767403 Disease Relevance 0.09 Pain Relevance 0.18
However, after in vivo THA, the inhibition of plasma ChE or brain AChE declined as a log function of tissue dilution.
Negative_regulation (declined) of Negative_regulation (inhibition) of AChE in brain
3) Confidence 0.33 Published 1989 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2602408 Disease Relevance 0.15 Pain Relevance 0.14
Systemic manipulations using the acetylcholinesterase inhibitor physostigmine (2.39±0.9 mg/kg, n?
Negative_regulation (using) of Negative_regulation (inhibitor) of acetylcholinesterase
4) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289875 Disease Relevance 0 Pain Relevance 0.27

General Comments

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