INT273675

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 8.69
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACACB) small molecule metabolic process (ACACB) Golgi apparatus (ACACB)
ligase activity (ACACB) cytoplasm (ACACB)
Anatomy Link Frequency
HeLa 1
ACACB (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 19 87.92 High High
depression 10 30.40 Quite Low
Angina 10 27.52 Quite Low
Osteoarthritis 10 24.00 Low Low
anesthesia 4 7.00 Low Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 99.88 Very High Very High Very High
Renal Disease 244 99.76 Very High Very High Very High
Proteinuria 72 99.76 Very High Very High Very High
Nicotine Addiction 30 99.54 Very High Very High Very High
Diabetes Mellitus 280 99.32 Very High Very High Very High
Myelodysplastic Syndromes 60 98.34 Very High Very High Very High
Metabolic Syndrome 4 96.76 Very High Very High Very High
Chronic Renal Failure 52 95.12 Very High Very High Very High
Frailty 15 89.40 High High
Obesity 28 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of the ACACB with diabetic nephropathy could not be replicated in patients with type 1 diabetes, although these nephropathy cases had proteinuria.
ACACB Binding (Association) of associated with diabetes mellitus, proteinuria and renal disease
1) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 2.53 Pain Relevance 0
Because the statistical power of this study for patients with type 1 diabetes was probably not sufficient, the association of variations in ACACB with diabetic nephropathy in patients with type 1 diabetes should be re-evaluated in future studies.
ACACB Binding (association) of associated with diabetes mellitus and renal disease
2) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 2.17 Pain Relevance 0
The association of the ACACB locus with diabetic nephropathy in the replication study was evaluated with the Armitage test for trends using an additive model, as described previously [34].
ACACB Binding (association) of associated with renal disease
3) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 0.10 Pain Relevance 0
Since the presence of proteinuria is also recognized as a predictor of cardio-vascular diseases, the association of ACACB with proteinuria might reflect an association between the gene and cardio-vascular diseases or metabolic syndrome.
ACACB Binding (association) of associated with proteinuria, metabolic syndrome and increased venous pressure under development
4) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2820513 Disease Relevance 2.31 Pain Relevance 0
Surprisingly, the STR profiles of these three cell lines were almost identical to that of HeLa cells, except for vWA in ACC2/Sa, ACC3 and ACCM (Table 1, and Figures 1 and S1).
ACC2 Neg (except) Binding (vWA) of in HeLa
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698276 Disease Relevance 0 Pain Relevance 0
Our STR analysis demonstrated that our ACC2, ACC3, and ACCM cells had nearly identical electrophoretic profiles (Table 1, and Figures 1 and S1, S2, S3, S4, S5, S6, S7, S8, S9, S10).
ACC2 Binding (our) of
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698276 Disease Relevance 0.08 Pain Relevance 0
To further investigate associations found for HACC use overall, we examined use of specific types of HACC service.
HACC Binding (associations) of
7) Confidence 0.11 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2887872 Disease Relevance 0.08 Pain Relevance 0
Carers could be identified in HACC MDS version 1 data; a preliminary analysis using only this version found that 3.4% of HACC clients were carers only; excluding these participants had very little impact on effect estimates for associations with key predictor variables.
HACC Binding (associations) of associated with myelodysplastic syndromes
8) Confidence 0.11 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2887872 Disease Relevance 0.61 Pain Relevance 0
Current smoking was also higher among HACC clients, indicating the potential to engage this client group in targeted smoking prevention programs.
HACC Binding (engage) of associated with nicotine addiction
9) Confidence 0.11 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2887872 Disease Relevance 0.55 Pain Relevance 0.09
To explore associations between HACC use, lifestyle factors and health conditions, we calculated RRs adjusted for sex, age, relationship status and income.
HACC Binding (associations) of
10) Confidence 0.11 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2887872 Disease Relevance 0.05 Pain Relevance 0
Our innovative linkage of the 45 and Up Study with HACC program data has shown that socio-demographic vulnerability (in particular, low income and not having a partner) and health needs are strong predictors of HACC service use.
HACC Binding (linkage) of
11) Confidence 0.11 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2887872 Disease Relevance 0.22 Pain Relevance 0

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