INT273704

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb2)
Anatomy Link Frequency
lung 1
Itgb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 100.00 Very High Very High Very High
antagonist 14 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
fluoxetine 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Desipramine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Autoimmune Disease 6 100.00 Very High Very High Very High
Immune System Diseases 2 100.00 Very High Very High Very High
Disease 4 98.40 Very High Very High Very High
Mycobacterial Infection 145 97.96 Very High Very High Very High
Infection 112 96.20 Very High Very High Very High
Necrosis 3 81.80 Quite High
Cancer 3 81.44 Quite High
Granuloma 5 71.60 Quite High
Adhesions 4 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, LFA-1 is implicated in various immunologic diseases such as chronic inflammation and autoimmune diseases and has been identified as a target for development of drugs against those diseases [3], [4].
LFA-1 Binding (target) of associated with autoimmune disease, inflammation, disease and immune system diseases
1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.64 Pain Relevance 0.10
LFA-1/ICAM-1 interaction played a critical role in the pMV-absorption.
LFA-1 Binding (interaction) of
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
Integrins CD11a and CD18 have been shown to be critical for recruitment of T cells to the lung and to confer host resistance following infection with aerosolized M.tuberculosis [31].
CD18 Binding (Integrins) of in lung associated with mycobacterial infection and infection
3) Confidence 0.12 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.95 Pain Relevance 0

General Comments

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