INT273717

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Icam1, Itgb2) extracellular space (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
T cell 2
Icam1 (Mus musculus)
Itgb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 80.72 Quite High
antagonist 28 5.00 Very Low Very Low Very Low
antidepressant 24 5.00 Very Low Very Low Very Low
fluoxetine 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
Desipramine 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Disease 4 85.04 High High
Autoimmune Disease 12 81.68 Quite High
Targeted Disruption 24 81.52 Quite High
INFLAMMATION 16 80.72 Quite High
Immune System Diseases 4 79.56 Quite High
Infection 4 67.80 Quite High
Syndrome 8 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.
intercellular adhesion molecule-1 Binding (ligand) of LFA-1 in T cell associated with adhesions
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.72 Pain Relevance 0.07
When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.
ICAM-1 Binding (ligand) of LFA-1 in T cell associated with adhesions
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.73 Pain Relevance 0.07
LFA-1/ICAM-1 interaction played a critical role in the pMV-absorption.
ICAM-1 Binding (interaction) of LFA-1
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0
LFA-1/ICAM-1 interaction played a critical role in the pMV-absorption.
ICAM-1 Binding (interaction) of LFA-1
4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0

General Comments

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