INT273723

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.97
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
T cell 4
Icam1 (Mus musculus)
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 85.12 High High
antagonist 28 5.00 Very Low Very Low Very Low
antidepressant 24 5.00 Very Low Very Low Very Low
fluoxetine 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
Desipramine 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Disease 4 89.44 High High
Autoimmune Disease 12 86.08 High High
Targeted Disruption 24 85.72 High High
INFLAMMATION 16 85.12 High High
Immune System Diseases 4 83.96 Quite High
Infection 4 72.20 Quite High
Syndrome 8 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The eMV-absorption by 2C T cells was found to be mediated by specific dual receptor/ligand interactions of 2C TCR with a cognate pMHC (Ld/QL9 or Ld/p2Ca) plus LFA-1 with ICAM-1.
ICAM-1 Binding (interactions) of 2C TCR in T cells
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.47 Pain Relevance 0.03
When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.
intercellular adhesion molecule-1 Binding (interaction) of TCR in T cell associated with adhesions
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.75 Pain Relevance 0.08
When the ‘inside-out’ signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.
ICAM-1 Binding (interaction) of TCR in T cell associated with adhesions
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0.75 Pain Relevance 0.08
Secondly, using 2C T cells deficient in CD28 or LFA-1 expression and mAbs blocking interactions of those receptors with their ligands, it is feasible to probe the contributing roles of TCR/pMHC, CD28/B7-1 and LFA-1/ICAM-1 interactions in the pMV-absorption.

2C T cell absorption of LdB7-1ICAM-1 Dros pMVs

ICAM-1 Binding (interactions) of TCR in T cell
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0

General Comments

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