INT273759

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
plasma 2
T cells 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 37.36 Quite Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 67 99.98 Very High Very High Very High
Immunodeficiency 2 99.52 Very High Very High Very High
Infection 66 98.80 Very High Very High Very High
Cold Sores 76 98.40 Very High Very High Very High
Disease Progression 15 79.36 Quite High
Disease 16 71.96 Quite High
Adult T-cell Leukemia-lymphoma 7 67.24 Quite High
Leukemia 5 61.00 Quite High
Herpes Simplex Virus 3 50.00 Quite Low
INFLAMMATION 6 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, two sides of the observed association deserve further evaluation: 1) HIV induced CD4+ T cell loss directly correlated with the degree of HSV-2 activity or frequent symptomatic HSV-2 reactivations; and 2) active HSV-2 infection with frequent HSV-2 reactivations was, in turn, associated with modestly elevated plasma HIV RNA levels and reduced CD4+ T cell count over time, compared to women remaining clinically asymptomatic after adjusting for baseline CD4+ T cell levels.
Positive_regulation (induced) of Negative_regulation (loss) of CD4 in plasma associated with cold sores, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848613 Disease Relevance 1.33 Pain Relevance 0
The loss of CD4+ T cells could induce a state of immunodeficiency in older individuals.
Positive_regulation (induce) of Negative_regulation (loss) of CD4 in T cells associated with immunodeficiency
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698465 Disease Relevance 0.72 Pain Relevance 0

General Comments

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