INT273866

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.69
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mul1) mitochondrion (Mul1) peroxisome (Mul1)
nucleus (Mul1) ligase activity (Mul1) cytoplasm (Mul1)
Anatomy Link Frequency
Notch 1
Mul1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 16 63.84 Quite High
Inflammation 16 57.36 Quite High
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Sciatic nerve 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Frailty 8 95.00 High High
Hypertrophy 2 91.48 High High
Systemic Lupus Erythematosus 61 61.72 Quite High
INFLAMMATION 16 57.36 Quite High
Muscular Atrophy 18 55.60 Quite High
Body Weight 16 27.96 Quite Low
Autoimmune Disease 23 25.92 Quite Low
Injury 3 10.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, Siah1, which belongs to the E3 ubiquitin ligase complex, is known to promote degradation of Numb, and thereby leads to activation of Notch [68]–[71].
E3 ubiquitin ligase Binding (complex) of in Notch
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
These activated kinases recruit tumor necrosis factor receptor-associated factor (TRAF) 6, which is an E3 ubiquitin ligase required for activation of NF?
E3 ubiquitin ligase Binding (recruit) of associated with necrosis and cancer
2) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.37 Pain Relevance 0.09
Furthermore, they appear able to access only sarcoplasmic, not sarcomeric myosin [9], [38], and their E3 ligase activity does not require further activation once they have recognized their substrate.
E3 ligase Binding (activity) of
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
Here we present evidence that the Ozz-E3 ligase, by binding to the rod domain of a fully assembled MyHCemb, marks it for ubiquitination and degradation, probably facilitating the subsequent assembly of new isoforms.
E3 ligase Binding (binding) of
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.32 Pain Relevance 0

General Comments

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