INT273921

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 91.92 High High
adenocard 1 82.40 Quite High
Potency 1 67.84 Quite High
Thermal hyperalgesia 18 50.00 Quite Low
Pain 15 38.88 Quite Low
Inflammation 34 35.36 Quite Low
Antinociceptive 1 32.40 Quite Low
IPN 16 26.36 Quite Low
Peripheral sensitization 1 21.16 Low Low
Central nervous system 3 16.64 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 54 85.84 High High
Hyperalgesia 33 50.00 Quite Low
Pain 14 38.88 Quite Low
INFLAMMATION 36 35.36 Quite Low
Inflammatory Pain 17 26.36 Quite Low
Neuropathic Pain 1 25.20 Quite Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low
Convulsion 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the NO signaling pathway can mediate the expression of CREB target genes by controlling CREB-DNA binding, which is independent of CREB phosphorylation [62].
Regulation (controlling) of CREB-DNA Binding (binding) of
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.28 Pain Relevance 0.16
However, the outcome of CRE-mediated gene transcription does not solely depend on CREB binding, but on the competitive binding of several dimerized transcription factors, including activators and repressors of gene transcription.
Neg (not) Regulation (depend) of CREB Binding (binding) of
2) Confidence 0.15 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0

General Comments

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