INT273930

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cst8) cytoplasm (Cst8)
Cst8 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 42.92 Quite Low
depression 5 39.76 Quite Low
addiction 4 20.04 Low Low
cytokine 13 13.68 Low Low
Neurotransmitter 3 10.08 Low Low
Dopamine 5 9.40 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
amygdala 10 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
Eae 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 86.88 High High
Eating Disorder 1 40.64 Quite Low
Depression 5 39.76 Quite Low
Pituitary Acth Hypersecretion 1 39.28 Quite Low
Hyponatremia 5 37.44 Quite Low
Stress 39 27.08 Quite Low
Anxiety Disorder 16 25.56 Quite Low
Drug Dependence 4 20.04 Low Low
Brain Injury 1 19.24 Low Low
Disease 1 18.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ICER is a transcription repressor, and after reaching a certain concentration, starts to suppress CRE-dependent activation of gene expression, including its own expression (through the formation of ICER homodimers or ICER-CREB heterodimers that bind to CREs and block transcription).
CREs Binding (bind) of
1) Confidence 0.07 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.09 Pain Relevance 0
However, the direct binding of CREB proteins to these putative CREs has not been verified by electrophoretic mobility shift assay (EMSA) or chromatin immunoprecipitation (ChIP).
CREs Binding (binding) of
2) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0

General Comments

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